GSTP1

Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases. [provided by RefSeq, Jul 2008]

Glutathione S-Transferase Pi 1

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed:9084911).

Participates in the formation of novel hepoxilin regioisomers (PubMed:21046276).

Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.

Cellular response to lipopolysaccharide Source: BHF-UCL
Central nervous system development Source: ProtInc
Common myeloid progenitor cell proliferation Source: BHF-UCL
Glutathione derivative biosynthetic process Source: UniProtKB
Glutathione metabolic process Source: UniProtKB
Hepoxilin biosynthetic process Source: UniProtKB
Linoleic acid metabolic process Source: BHF-UCL
Negative regulation of acute inflammatory response Source: BHF-UCL
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of biosynthetic process Source: BHF-UCL
Negative regulation of ERK1 and ERK2 cascade Source: BHF-UCL
Negative regulation of extrinsic apoptotic signaling pathway Source: BHF-UCL
Negative regulation of fibroblast proliferation Source: BHF-UCL
Negative regulation of I-kappaB kinase/NF-kappaB signaling Source: BHF-UCL
Negative regulation of interleukin-1 beta production Source: BHF-UCL
Negative regulation of JUN kinase activity Source: BHF-UCL
Negative regulation of leukocyte proliferation Source: BHF-UCL
Negative regulation of MAPK cascade Source: BHF-UCL
Negative regulation of MAP kinase activity Source: BHF-UCL
Negative regulation of monocyte chemotactic protein-1 production Source: BHF-UCL
Negative regulation of nitric-oxide synthase biosynthetic process Source: BHF-UCL
Negative regulation of protein kinase activity Source: BHF-UCL
Negative regulation of stress-activated MAPK cascade Source: BHF-UCL
Negative regulation of tumor necrosis factor-mediated signaling pathway Source: BHF-UCL
Negative regulation of tumor necrosis factor production Source: BHF-UCL
Nitric oxide storage Source: BHF-UCL
Positive regulation of superoxide anion generation Source: BHF-UCL
Prostaglandin metabolic process Source: UniProtKB
Regulation of ERK1 and ERK2 cascade Source: BHF-UCL
Regulation of stress-activated MAPK cascade Source: BHF-UCL
Response to reactive oxygen species Source: BHF-UCL
Xenobiotic metabolic process Source: UniProtKB

Cytoplasm; Nucleus; Mitochondrion. The 83 N-terminal amino acids function as un uncleaved transit peptide, and arginine residues within it are crucial for mitochondrial localization.