GRM2

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Several transcript variants encoding different isoforms have been found for this gene.

glutamate metabotropic receptor 2

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization.

Behavioral response to nicotine Source: Ensembl
Chemical synaptic transmission Source: ProtInc
Gene expression Source: Ensembl
Glutamate homeostasis Source: Ensembl
Glutamate secretion Source: Ensembl
G protein-coupled glutamate receptor signaling pathway Source: GO_Central
Negative regulation of adenylate cyclase activity Source: ProtInc
Regulation of dopamine secretion Source: Ensembl
Regulation of glutamate secretion Source: Ensembl
Regulation of protein kinase B signaling Source: ARUK-UCL
Regulation of response to drug Source: Ensembl
Regulation of synaptic transmission, glutamatergic Source: GO_Central
Response to cocaine Source: Ensembl

Cell membrane; Synapse; Dendrite

Extracellular: 19-567
Helical: 568-590
Cytoplasmic: 591-604
Helical: 605-625
Extracellular: 626-636
Helical: 637-655
Cytoplasmic: 656-679
Helical: 680-700
Extracellular: 701-725
Helical: 726-747
Cytoplasmic: 748-760
Helical: 761-783
Extracellular: 784-793
Helical: 794-819
Cytoplasmic: 820-872