GRIP1

This gene encodes a member of the glutamate receptor interacting protein family. The encoded scaffold protein binds to and mediates the trafficking and membrane organization of a number of transmembrane proteins. Alternatively spliced transcript variants encoding different isoforms have been described.

Glutamate Receptor Interacting Protein 1

May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons (PubMed:10197531).

Through complex formation with NSG1, GRIA2 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity).

Dendrite development Source: InterPro
Intracellular signal transduction Source: UniProtKB
Neurotransmitter receptor transport, endosome to postsynaptic membrane Source: GO_Central
Positive regulation of neuron projection arborization Source: ARUK-UCL
Vesicle-mediated transport in synapse Source: Ensembl

Postsynaptic cell membrane; Endoplasmic reticulum membrane; Cytoplasm; Cytoplasmic vesicle; Perikaryon; Dendrite; Endomembrane system; Postsynaptic density. Membrane-associated with vesicles, peri-Golgi complexes and endoplasmic reticulum. Enriched in postsynaptic plasma membrane and postsynaptic densities.

Fraser syndrome 3 (FRASRS3):
A form of Fraser syndrome, an autosomal recessive disorder characterized by cryptophthalmos, cutaneous syndactyly, and urogenital abnormalities including renal agenesis or hypoplasia. Additional features include abnormalities of the larynx, ear malformations, and facial abnormalities.