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Mouse Anti-GRIP1 Recombinant Antibody (CBLG1-1774) (CBMAB-G4970-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBLG1-1774
Antibody Isotype
IgG2a, κ
Application
ELISA, ELISA (Cap), WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Glutamate Receptor Interacting Protein 1
Introduction
This gene encodes a member of the glutamate receptor interacting protein family. The encoded scaffold protein binds to and mediates the trafficking and membrane organization of a number of transmembrane proteins. Alternatively spliced transcript variants encoding different isoforms have been described.
Entrez Gene ID
23426
UniProt ID
Q9Y3R0
Alternative Names
FRASRS3; GRIP
Function
May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons (PubMed:10197531).

Through complex formation with NSG1, GRIA2 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity).
Biological Process
Dendrite development Source: InterPro
Intracellular signal transduction Source: UniProtKB
Neurotransmitter receptor transport, endosome to postsynaptic membrane Source: GO_Central
Positive regulation of neuron projection arborization Source: ARUK-UCL
Vesicle-mediated transport in synapse Source: Ensembl
Cellular Location
Postsynaptic cell membrane; Endoplasmic reticulum membrane; Cytoplasm; Cytoplasmic vesicle; Perikaryon; Dendrite; Endomembrane system; Postsynaptic density. Membrane-associated with vesicles, peri-Golgi complexes and endoplasmic reticulum. Enriched in postsynaptic plasma membrane and postsynaptic densities.
Involvement in disease
Fraser syndrome 3 (FRASRS3):
A form of Fraser syndrome, an autosomal recessive disorder characterized by cryptophthalmos, cutaneous syndactyly, and urogenital abnormalities including renal agenesis or hypoplasia. Additional features include abnormalities of the larynx, ear malformations, and facial abnormalities.
More Infomation

Han, Y., Chen, L., Liu, J., Chen, J., Wang, C., Guo, Y., ... & Ma, H. (2022). A class I HDAC inhibitor rescues synaptic damage and neuron loss in APP-transfected cells and APP/PS1 mice through the GRIP1/AMPA pathway. Molecules, 27(13), 4160.

Hu, X., Deng, S., Luo, L., Jiang, Y., Ge, H., Yin, F., ... & Feng, J. (2021). GLCCI1 Deficiency Induces Glucocorticoid Resistance via the Competitive Binding of IRF1: GRIP1 and IRF3: GRIP1 in Asthma. Frontiers in Medicine, 8, 686493.

Bissen, D., Kracht, M. K., Foss, F., Hofmann, J., & Acker-Palmer, A. (2021). EphrinB2 and GRIP1 stabilize mushroom spines during denervation-induced homeostatic plasticity. Cell Reports, 34(13), 108923.

Koprulu, M., Kumare, A., Bibi, A., Malik, S., & Tolun, A. (2021). The first adolescent case of Fraser syndrome 3, with a novel nonsense variant in GRIP1. American Journal of Medical Genetics Part A, 185(6), 1858-1863.

Tan, H. L., Chiu, S. L., Zhu, Q., & Huganir, R. L. (2020). GRIP1 regulates synaptic plasticity and learning and memory. Proceedings of the National Academy of Sciences, 117(40), 25085-25091.

Mimouna, S., Rollins, D. A., Shibu, G., Tharmalingam, B., Deochand, D. K., Chen, X., ... & Rogatsky, I. (2020). Transcription cofactor GRIP1 differentially affects myeloid cell–driven neuroinflammation and response to IFN-β therapy. Journal of Experimental Medicine, 218(1), e20192386.

Twelvetrees, A. E., Lesept, F., Holzbaur, E. L., & Kittler, J. T. (2019). The adaptor proteins HAP1a and GRIP1 collaborate to activate the kinesin-1 isoform KIF5C. Journal of cell science, 132(24), jcs215822.

Mejias, R., Chiu, S. L., Han, M., Rose, R., Gil-Infante, A., Zhao, Y., ... & Wang, T. (2019). Purkinje cell-specific Grip1/2 knockout mice show increased repetitive self-grooming and enhanced mGluR5 signaling in cerebellum. Neurobiology of disease, 132, 104602.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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