GABPA

This gene encodes one of three GA-binding protein transcription factor subunits which functions as a DNA-binding subunit. Since this subunit shares identity with a subunit encoding the nuclear respiratory factor 2 gene, it is likely involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. This subunit also shares identity with a subunit constituting the transcription factor E4TF1, responsible for expression of the adenovirus E4 gene. Because of its chromosomal localization and ability to form heterodimers with other polypeptides, this gene may play a role in the Down Syndrome phenotype. Two transcript variants encoding the same protein have been found for this gene.

GA binding protein transcription factor subunit alpha

Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the expression of the Adenovirus E4 gene.

Blastocyst formation Source: Ensembl
Cell differentiation Source: GO_Central
Cellular response to dopamine Source: CAFA
Negative regulation of megakaryocyte differentiation Source: Ensembl
Negative regulation of transcription by RNA polymerase II Source: Ensembl
Positive regulation of gene expression Source: CAFA
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central

Nucleus