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Mouse Anti-GABPA Recombinant Antibody (CBLG1-430) (CBMAB-G1629-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBLG1-430
Antibody Isotype
IgG1, κ
Application
IF, WB

Basic Information

Immunogen
GABPA (AAH35031, 1 a.a. ~ 454 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
GA binding protein transcription factor subunit alpha
Introduction
This gene encodes one of three GA-binding protein transcription factor subunits which functions as a DNA-binding subunit. Since this subunit shares identity with a subunit encoding the nuclear respiratory factor 2 gene, it is likely involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. This subunit also shares identity with a subunit constituting the transcription factor E4TF1, responsible for expression of the adenovirus E4 gene. Because of its chromosomal localization and ability to form heterodimers with other polypeptides, this gene may play a role in the Down Syndrome phenotype. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2010]
Entrez Gene ID
2551
UniProt ID
Q06546
Alternative Names
GA Binding Protein Transcription Factor Alpha Subunit; Human Nuclear Respiratory Factor-2 Subunit Alpha; Nuclear Respiratory Factor 2 Alpha Subunit; Nuclear Respiratory Factor 2 Subunit Alpha; Transcription Factor E4TF1-60; GABP Subunit Alpha; E4TF1A; GA-Binding Protein Transcription Factor; Alpha Subunit (60kD); GA Binding Protein Transcription Factor; Alpha Subunit 60kDa;
Function
Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the expression of the Adenovirus E4 gene.
Biological Process
Blastocyst formation Source: Ensembl
Cell differentiation Source: GO_Central
Cellular response to dopamine Source: CAFA
Negative regulation of megakaryocyte differentiation Source: Ensembl
Negative regulation of transcription by RNA polymerase II Source: Ensembl
Positive regulation of gene expression Source: CAFA
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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