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FUCA1

The protein encoded by this gene is a lysosomal enzyme involved in the degradation of fucose-containing glycoproteins and glycolipids. Mutations in this gene are associated with fucosidosis (FUCA1D), which is an autosomal recessive lysosomal storage disease. A pseudogene of this locus is present on chr 2.[provided by RefSeq, Oct 2009]

Full Name

Alpha-L-Fucosidase 1

Function

Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.

Biological Process

Fucose metabolic process Source: UniProtKB
Glycolipid catabolic process Source: BHF-UCL
Glycosaminoglycan catabolic process Source: UniProtKB
Glycoside catabolic process Source: UniProtKB

Cellular Location

Lysosome

Involvement in disease

Fucosidosis (FUCA1D):
An autosomal recessive lysosomal storage disease characterized by accumulation of fucose-containing glycolipids and glycoproteins in various tissues. Clinical signs include facial dysmorphism, dysostosis multiplex, moderate hepatomegaly, severe intellectual deficit, deafness, and according to age, angiokeratomas.

Anti-FUCA1 antibodies

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Mouse Anti-FUCA1 Recombinant Antibody (CBYJT-1284) (CBMAB-T0299-YJ)

SDS

Target: FUCA1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJT-1284

Application*: WB

Mouse Anti-FUCA1 Recombinant Antibody (CBYC-A959) (CBMAB-A4412-YC)

SDS

Target: FUCA1

Host: Mouse

Antibody Isotype: IgG

Specificity: Rat

Clone: CBYC-A959

Application*: WB, IC, P, C, E

Mouse Anti-FUCA1 Recombinant Antibody (CBYC-A958) (CBMAB-A4411-YC)

SDS

Target: FUCA1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBYC-A958

Application*: WB, IC, P, C, E

Mouse Anti-FUCA1 Recombinant Antibody (1D4) (CBMAB-A4409-YC)

SDS

Target: FUCA1

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 1D4

Application*: E, WB

Mouse Anti-FUCA1 (AA 32-466) Recombinant Antibody (CBXF-3232) (CBMAB-F3927-CQ)

SDS

Target: FUCA1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXF-3232

Application*: E, WB

Rabbit Anti-FUCA1 Recombinant Antibody (CBXF-1101) (CBMAB-F0993-CQ)

SDS

Target: FUCA1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse

Clone: CBXF-1101

Application*: WB, F

Mouse Anti-FUCA1 Recombinant Antibody (CBXF-0955) (CBMAB-F0992-CQ)

SDS

Target: FUCA1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBXF-0955

Application*: WB

FUCA1 Matched Antibody Pair (456) (APMAB-456LY)

SDS

Target: FUCA1

Specificity: Human

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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