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FUCA1 Matched Antibody Pair (456) (APMAB-456LY)


See all FUCA1 antibodies
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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Mouse anti-FUCA1 monoclonal antibody, 100 ug
Detection Antibody
Anti-FUCA1 Rabbit polyclonal antibody, 50 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
The protein encoded by this gene is a lysosomal enzyme involved in the degradation of fucose-containing glycoproteins and glycolipids. Mutations in this gene are associated with fucosidosis (FUCA1D), which is an autosomal recessive lysosomal storage disease. A pseudogene of this locus is present on chr 2.[provided by RefSeq, Oct 2009]
Alternative Names
Alpha-L-Fucosidase 1; Alpha-L-Fucoside Fucohydrolase 1; Fucosidase, Alpha-L- 1, Tissue; Alpha-L-Fucosidase I; Tissue Fucosidase; A-L-Fucosidase 1;
Entrez Gene ID
2517
UniProt ID
P04066
More Infomation

Xiao, Y., Jiang, X., Yin, K., Miao, T., Lu, H., Wang, W., ... & Zhang, P. (2023). USP35 promotes cell proliferation and chemotherapeutic resistance through stabilizing FUCA1 in colorectal cancer. Oncogenesis, 12(1), 12.

Armstrong, Z., Meek, R. W., Wu, L., Blaza, J. N., & Davies, G. J. (2022). Cryo-EM structures of human fucosidase FucA1 reveal insight into substrate recognition and catalysis. Structure, 30(10), 1443-1451.

Barelier, S., & Sulzenbacher, G. (2022). The long-awaited structure of human fucosidase FucA1 opens novel avenues for the treatment of fucosidosis. Structure, 30(10), 1369-1371.

Chkioua, L., Amri, Y., Saheli, C., Fenni, F., Boudabous, H., Ben Turkia, H., ... & Laradi, S. (2021). Fucosidosis in Tunisian patients: mutational analysis and homology-based modeling of FUCA1 enzyme. BMC medical genomics, 14, 1-11.

Zhang, X., Zhao, S., Liu, H., Wang, X., Wang, X., Du, N., ... & Duan, H. (2021). Identification of a novel homozygous loss-of-function mutation in FUCA1 gene causing severe fucosidosis: A case report. Journal of International Medical Research, 49(4), 03000605211005975.

Domin, A., Zabek, T., Kwiatkowska, A., Szmatola, T., Deregowska, A., Lewinska, A., ... & Wnuk, M. (2021). The Identification of a Novel Fucosidosis-Associated FUCA1 Mutation: A Case of a 5-Year-Old Polish Girl with Two Additional Rare Chromosomal Aberrations and Affected DNA Methylation Patterns. Genes, 12(1), 74.

Wali, G., Wali, G. M., Sue, C. M., & Kumar, K. R. (2019). A novel homozygous mutation in the FUCA1 gene highlighting fucosidosis as a cause of dystonia: Case report and literature review. Neuropediatrics, 50(04), 248-252.

Bonin, S., Parascandolo, A., Aversa, C., Barbazza, R., Tsuchida, N., Castellone, M. D., ... & Vecchio, G. (2018). Reduced expression of α-L-Fucosidase-1 (FUCA-1) predicts recurrence and shorter cancer specific survival in luminal B LN+ breast cancer patients. Oncotarget, 9(20), 15228.

Valero‐Rubio, D., Jiménez, K. M., Fonseca, D. J., Payán‐Gómez, C., & Laissue, P. (2018). Transcriptomic analysis of FUCA 1 knock‐down in keratinocytes reveals new insights into the pathogenesis of fucosidosis skin lesions. Experimental dermatology, 27(6), 663-667.

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For research use only. Not intended for any clinical use.

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