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FLI1

This gene encodes a transcription factor containing an ETS DNA-binding domain. The gene can undergo a t(11;22)(q24;q12) translocation with the Ewing sarcoma gene on chromosome 22, which results in a fusion gene that is present in the majority of Ewing sarcoma cases. An acute lymphoblastic leukemia-associated t(4;11)(q21;q23) translocation involving this gene has also been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

Full Name

Friend leukemia integration 1 transcription factor

Function

Sequence-specific transcriptional activator (PubMed:24100448, PubMed:26316623, PubMed:28255014).

Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'.

Biological Process

Animal organ morphogenesis Source: ProtInc
Blood circulation Source: Ensembl
Cell differentiation Source: GO_Central
Hemostasis Source: ProtInc
Megakaryocyte development Source: Ensembl
Positive regulation of transcription, DNA-templated Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central

Cellular Location

Nucleus

Involvement in disease

Ewing sarcoma (ES):
A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors.
Bleeding disorder, platelet-type, 21 (BDPLT21):
A disorder characterized by increased bleeding tendency due to platelet dysfunction. Clinical features include epistaxis, hematomas, bleeding after tooth extraction, and menorrhagia. BDPLT21 patients may have mild to moderate thrombocytopenia.

Anti-FLI1 antibodies

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Mouse Anti-Fli1 Recombinant Antibody (B2) (CBMAB-BR179LY)

SDS

Target: FLI1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: B2

Application*: WB

Mouse Anti-FLI1 Recombinant Antibody (IHC576) (CBMAB-MA091-YC)

SDS

Target: FLI1

Host: Mouse

Specificity: Human

Clone: IHC576

Application*: IH

Rabbit Anti-FLI1 Recombinant Antibody (D7N5M) (CBMAB-CP0718-LY)

SDS

Target: FLI1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat, Zebrafish

Clone: D7N5M

Application*: WB, IP

Mouse Anti-FLI1 Recombinant Antibody (1H4) (CBMAB-A3006-LY)

SDS

Target: FLI1

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 1H4

Application*: WB, E

Mouse Anti-FLI1 Recombinant Antibody (1F6) (CBMAB-A3004-LY)

SDS

Target: FLI1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human, Rat

Clone: 1F6

Application*: WB, E

Mouse Anti-FLI1 Recombinant Antibody (2E6) (CBMAB-A3003-LY)

SDS

Target: FLI1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 2E6

Application*: WB, E

Mouse Anti-FLI1 Recombinant Antibody (CBXF-3070) (CBMAB-F3767-CQ)

SDS

Target: FLI1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human, Rat

Clone: CBXF-3070

Application*: E, WB

Mouse Anti-FLI1 Recombinant Antibody (CBXF-3069) (CBMAB-F3766-CQ)

SDS

Target: FLI1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CBXF-3069

Application*: E, IP, WB

Mouse Anti-FLI1 Recombinant Antibody (CBXF-3065) (CBMAB-F3762-CQ)

SDS

Target: FLI1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBXF-3065

Application*: E, IF, WB

Mouse Anti-FLI1 Recombinant Antibody (CBXF-1754) (CBMAB-F3289-CQ)

SDS

Target: FLI1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CBXF-1754

Application*: WB, IP, IF, E

Mouse Anti-FLI1 Recombinant Antibody (CBXF-1753) (CBMAB-F3288-CQ)

SDS

Target: FLI1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBXF-1753

Application*: WB, IP, IF, E

Mouse Anti-FLI1 Recombinant Antibody (CBXF-0735) (CBMAB-F3187-CQ)

SDS

Target: FLI1

Host: Mouse

Antibody Isotype: IgG2a, λ

Specificity: Human

Clone: CBXF-0735

Application*: IF, E, WB

Mouse Anti-FLI1 Recombinant Antibody (CBXF-2335) (CBMAB-F2814-CQ)

SDS

Target: FLI1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBXF-2335

Application*: IP

Mouse Anti-FLI1 Recombinant Antibody (G146-22) (CBMAB-F2564-CQ)

SDS

Target: FLI1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: G146-22

Application*: C, P

Mouse Anti-FLI1 Recombinant Antibody (FLVI1-1) (CBMAB-F2383-CQ)

SDS

Target: FLI1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: FLVI1-1

Application*: F, IF, WB

Mouse Anti-FLI1 Recombinant Antibody (CBXF-2242) (CBMAB-F1639-CQ)

SDS

Target: FLI1

Host: Mouse

Antibody Isotype: IgG3

Specificity: Human, Mouse

Clone: CBXF-2242

Application*: CI, IF, WB

Rabbit Anti-FLI1 Recombinant Antibody (CBXF-0734) (CBMAB-F1394-CQ)

SDS

Target: FLI1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat, Zebrafish

Clone: CBXF-0734

Application*: WB, IP

Mouse Anti-FLI1 Recombinant Antibody (CBXF-3716) (CBMAB-F1130-CQ)

SDS

Target: FLI1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBXF-3716

Application*: IF, WB

Mouse Anti-FLI1 (AA 1-453) Recombinant Antibody (CBXF-0733) (CBMAB-F0435-CQ)

SDS

Target: FLI1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBXF-0733

Application*: E, WB

Rabbit Anti-FLI1 Recombinant Antibody (CBXF-1202) (CBMAB-F0196-CQ)

SDS

Target: FLI1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse

Clone: CBXF-1202

Application*: WB, P

Mouse Anti-FLI1 Antibody (4H6) (CBMAB-0369-YC)

SDS

Target: FLI1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 4H6

Application*: IP, M

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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