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Mouse Anti-FLI1 Antibody (4H6) (CBMAB-0369-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
4H6
Antibody Isotype
IgG2a
Application
IP, MA

Basic Information

Immunogen
Recombinant protein
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Friend leukemia integration 1 transcription factor
Introduction
FLI1 (fli-1 proto-oncogene, ETS transcription factor) is a transcription factor containing an ETS DNA-binding domain. The FLI1 gene can undergo a t(11;22)(q24;q12) translocation with the Ewing sarcoma gene on chromosome 22, which results in a fusion gene that is present in the majority of Ewing sarcoma cases. An acute lymphoblastic leukemia-associated t(4;11)(q21;q23) translocation involving this gene has also been identified.
Entrez Gene ID
2313
UniProt ID
Q01543
Alternative Names
Fli-1 Proto-Oncogene, ETS Transcription Factor; Friend Leukemia Virus Integration 1; Transcription Factor ERGB; Ewing Sarcoma Breakpoint Region; Proto-Oncogene Fli-1; EWSR2; SIC-1
Function
Sequence-specific transcriptional activator (PubMed:24100448, PubMed:26316623, PubMed:28255014).

Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'.
Biological Process
Animal organ morphogenesis Source: ProtInc
Blood circulation Source: Ensembl
Cell differentiation Source: GO_Central
Hemostasis Source: ProtInc
Megakaryocyte development Source: Ensembl
Positive regulation of transcription, DNA-templated Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
Involvement in disease
Ewing sarcoma (ES):
A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors.
Bleeding disorder, platelet-type, 21 (BDPLT21):
A disorder characterized by increased bleeding tendency due to platelet dysfunction. Clinical features include epistaxis, hematomas, bleeding after tooth extraction, and menorrhagia. BDPLT21 patients may have mild to moderate thrombocytopenia.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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