FAM19A3

FAM19A3 is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to play a role as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for FAM19A3.

Family With Sequence Similarity 19 Member A3, C-C Motif Chemokine Like

Plays a role in the regulation of microglia polarization.

Negative regulation of microglial cell activation Source: UniProtKB
Neuroblast differentiation Source: GO_Central
Positive regulation of microglial cell activation Source: UniProtKB
Regulation of neuroblast proliferation Source: GO_Central

Secreted