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EPHB6

This gene encodes a member of a family of transmembrane proteins that function as receptors for ephrin-B family proteins. Unlike other members of this family, the encoded protein does not contain a functional kinase domain. Activity of this protein can influence cell adhesion and migration. Expression of this gene is downregulated during tumor progression, suggesting that the protein may suppress tumor invasion and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Full Name

EPH Receptor B6

Research Area

Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2.

Biological Process

Axon guidance Source: GO_Central
Central nervous system projection neuron axonogenesis Source: GO_Central
Positive regulation of kinase activity Source: GO_Central
Transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central

Cellular Location

Membrane
Isoform 3: Secreted

Topology

Extracellular: 32-594
Helical: 595-615
Cytoplasmic: 616-1021

PTM

Ligand-binding increases phosphorylation on tyrosine residues. Phosphorylation on tyrosine residues is mediated by transphosphorylation by the catalytically active EPHB1 in a ligand-independent manner. Tyrosine phosphorylation of the receptor may act as a switch on the functional transition from cell adhesion/attraction to de-adhesion/repulsion.

Anti-EPHB6 antibodies

Mouse Anti-EPHB6 Recombinant Antibody (CBFYH-3411) (CBMAB-H3956-FY)

SDS

Target: EPHB6

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human, Mouse, Rat

Clone: CBFYH-3411

Application*: E, WB, P

Mouse Anti-EPHB6 (AA 23-122) Recombinant Antibody (CBFYH-0156) (CBMAB-H1023-FY)

SDS

Target: EPHB6

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human, Mouse, Rat

Clone: CBFYH-0156

Application*: E, P, WB

Mouse Anti-EPHB6 Recombinant Antibody (CBFYE-1033) (CBMAB-E1544-FY)

SDS

Target: EPHB6

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBFYE-1033

Application*: F

Mouse Anti-EPHB6 Recombinant Antibody (CBFYE-1032) (CBMAB-E1543-FY)

SDS

Target: EPHB6

Host: Mouse

Specificity: Mouse, Rat, Human

Clone: CBFYE-1032

Application*: WB, IP, IF, E

Mouse Anti-EPHB6 (AA 601-750) Recombinant Antibody (CBFYE-1031) (CBMAB-E1542-FY)

SDS

Target: EPHB6

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYE-1031

Application*: E, IH, WB

Rabbit Anti-EPHB6 (AA 1-579) Recombinant Antibody (CBFYE-1030) (CBMAB-E1541-FY)

SDS

Target: EPHB6

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBFYE-1030

Application*: E

Mouse Anti-EPHB6 (AA 23-122) Recombinant Antibody (CBFYE-1029) (CBMAB-E1539-FY)

SDS

Target: EPHB6

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human, Mouse, Rat

Clone: CBFYE-1029

Application*: E, IH, WB

Mouse Anti-EPHB6 (AA 17-579) Recombinant Antibody (CBFYE-1026) (CBMAB-E1534-FY)

SDS

Target: EPHB6

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Mouse

Clone: CBFYE-1026

Application*: WB

Mouse Anti-EPHB6 (AA 17-579) Recombinant Antibody (CBFYE-0101) (CBMAB-E0208-FY)

SDS

Target: EPHB6

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYE-0101

Application*: F, MC

Mouse Anti-EPHB6 Recombinant Antibody (8E7H12) (CBMAB-E1537-FY)

SDS

Target: EPHB6

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 8E7H12

Application*: E, IH, P, WB

Mouse Anti-EPHB6 Recombinant Antibody (4A9C4F2) (CBMAB-E1540-FY)

SDS

Target: EPHB6

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 4A9C4F2

Application*: E

Mouse Anti-EPHB6 Recombinant Antibody (2A6B9) (CBMAB-E1536-FY)

SDS

Target: EPHB6

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 2A6B9

Application*: E, WB, P, IF, F

Rat Anti-EPHB6 Monoclonal Antibody (RM0057-9B17) (CBMAB-1171-YC)

SDS

Target: EPHB6

Host: Rat

Antibody Isotype: IgG2

Specificity: Mouse

Clone: RM0057-9B17

Application*: P, WB

Mouse Anti-EPHB6 Recombinant Antibody (5H6) (CBMAB-A2664-LY)

SDS

Target: EPHB6

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human, Mouse, Rat

Clone: 5H6

Application*: WB, E

Mouse Anti-EPHB6 Recombinant Antibody (5D8) (CBMAB-A2663-LY)

SDS

Target: EPHB6

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 5D8

Application*: WB, E

Mouse Anti-EPHB6 Recombinant Antibody (3B6) (CBMAB-A2662-LY)

SDS

Target: EPHB6

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human, Rat

Clone: 3B6

Application*: WB, E

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

Online Inquiry