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Mouse Anti-EPHB6 (AA 17-579) Recombinant Antibody (CBFYE-1026) (CBMAB-E1534-FY)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
CBFYE-1026
Antibody Isotype
IgG2b
Application
WB

Basic Information

Immunogen
Mouse myeloma cell line NS0-derived recombinant human EphB6, Val17-Thr579
Specificity
Human, Mouse
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, trehalose
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 17-579

Target

Full Name
EPH Receptor B6
Introduction
This gene encodes a member of a family of transmembrane proteins that function as receptors for ephrin-B family proteins. Unlike other members of this family, the encoded protein does not contain a functional kinase domain. Activity of this protein can influence cell adhesion and migration. Expression of this gene is downregulated during tumor progression, suggesting that the protein may suppress tumor invasion and metastasis. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
Human2051
Mouse13848
UniProt ID
HumanO15197
MouseO08644
Alternative Names
EPH Receptor B6; Tyrosine-Protein Kinase-Defective Receptor EPH-6; HEP; Human Kinase-Defective Eph-Family Receptor Protein; Ephrin Type-B Receptor 6; EC 2.7.10.1; EphB6
Research Area
Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2.
Biological Process
Axon guidance Source: GO_Central
Central nervous system projection neuron axonogenesis Source: GO_Central
Positive regulation of kinase activity Source: GO_Central
Transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
Cellular Location
Membrane
Isoform 3: Secreted
Topology
Extracellular: 32-594
Helical: 595-615
Cytoplasmic: 616-1021
PTM
Ligand-binding increases phosphorylation on tyrosine residues. Phosphorylation on tyrosine residues is mediated by transphosphorylation by the catalytically active EPHB1 in a ligand-independent manner. Tyrosine phosphorylation of the receptor may act as a switch on the functional transition from cell adhesion/attraction to de-adhesion/repulsion.
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For research use only. Not intended for any clinical use.

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