EFNB2

This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNB class ephrin which binds to the EPHB4 and EPHA3 receptors. [provided by RefSeq, Jul 2008]

Ephrin B2

Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons.

(Microbial infection) Acts as a receptor for Hendra virus and Nipah virus.

Anatomical structure morphogenesis Source: ProtInc
Axon guidance Source: GO_Central
Blood vessel morphogenesis Source: GO_Central
Cell adhesion Source: UniProtKB
Cell-cell signaling Source: ProtInc
Cell migration involved in sprouting angiogenesis Source: UniProtKB
Ephrin receptor signaling pathway Source: UniProtKB
Negative regulation of neuron projection development Source: ARUK-UCL
Positive regulation of cardiac muscle cell differentiation Source: BHF-UCL
Positive regulation of cell population proliferation Source: BHF-UCL
Positive regulation of neuron death Source: ARUK-UCL
Presynapse assembly Source: Ensembl
Regulation of chemotaxis Source: UniProtKB

Cell membrane; Adherens junction

Extracellular: 28-229
Helical: 230-250
Cytoplasmic: 251-333

Inducible phosphorylation of tyrosine residues in the cytoplasmic domain.