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Mouse Anti-EFNB2 Recombinant Antibody (CBFYE-0506) (CBMAB-E0862-FY)


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Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Human
Clone
CBFYE-0506
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Mouse, Rat, Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.2 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Ephrin B2
Introduction
This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNB class ephrin which binds to the EPHB4 and EPHA3 receptors.
Entrez Gene ID
Human1948
Mouse13642
Rat306636
UniProt ID
HumanP52799
MouseP52800
RatB2B9A9
Alternative Names
Ephrin B2; Eph-Related Receptor Tyrosine Kinase Ligand 5; HTK Ligand; Ligand Of Eph-Related Kinase 5; Ephrin-B2; LERK-5
Research Area
Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons.

(Microbial infection) Acts as a receptor for Hendra virus and Nipah virus.
Biological Process
Anatomical structure morphogenesis Source: ProtInc
Axon guidance Source: GO_Central
Blood vessel morphogenesis Source: GO_Central
Cell adhesion Source: UniProtKB
Cell-cell signaling Source: ProtInc
Cell migration involved in sprouting angiogenesis Source: UniProtKB
Ephrin receptor signaling pathway Source: UniProtKB
Negative regulation of neuron projection development Source: ARUK-UCL
Positive regulation of cardiac muscle cell differentiation Source: BHF-UCL
Positive regulation of cell population proliferation Source: BHF-UCL
Positive regulation of neuron death Source: ARUK-UCL
Presynapse assembly Source: Ensembl
Regulation of chemotaxis Source: UniProtKB
Cellular Location
Cell membrane; Adherens junction
Topology
Extracellular: 28-229
Helical: 230-250
Cytoplasmic: 251-333
PTM
Inducible phosphorylation of tyrosine residues in the cytoplasmic domain.
More Infomation

Lewis, A. E., Kuwahara, A., Franzosi, J., & Bush, J. O. (2022). Tracheal separation is driven by NKX2-1-mediated repression of Efnb2 and regulation of endodermal cell sorting. Cell reports, 38(11), 110510.

Sun, Y., Ma, L., Chen, J., Wang, W., Peng, S., Cheng, Y., ... & Ju, P. (2021). RNA-seq co-expression network analysis reveals anxiolytic behavior of mice with Efnb2 knockout in parvalbumin+ neurons. Molecular Brain, 14(1), 1-12.

Defourny, J., Audouard, C., Davy, A., & Thiry, M. (2021). Efnb2 haploinsufficiency induces early gap junction plaque disassembly and endocytosis in the cochlea. Brain Research Bulletin, 174, 153-160.

Xiong, C., Wen, Y., Zhao, J., Yin, D., Xu, L., Chelariu-Raicu, A., ... & Li, C. (2020). Targeting forward and reverse EphB4/EFNB2 signaling by a peptide with dual functions. Scientific reports, 10(1), 1-14.

Zhu, F., Dai, S. N., Xu, D. L., Hou, C. Q., Liu, T. T., Chen, Q. Y., ... & Miao, Y. (2020). EFNB2 facilitates cell proliferation, migration, and invasion in pancreatic ductal adenocarcinoma via the p53/p21 pathway and EMT. Biomedicine & Pharmacotherapy, 125, 109972.

Scherer, D., Deutelmoser, H., Balavarca, Y., Toth, R., Habermann, N., Buck, K., ... & Ulrich, C. M. (2020). Polymorphisms in the angiogenesis-related genes EFNB2, MMP2 and JAG1 are associated with survival of colorectal cancer patients. International journal of molecular sciences, 21(15), 5395.

Ni, Q., Chen, P., Zhu, B., Li, J., Xie, D., & Ma, X. (2020). Expression levels of EPHB4, EFNB2 and caspase‑8 are associated with clinicopathological features and progression of esophageal squamous cell cancer. Oncology Letters, 19(1), 917-929.

Li, Y., Chen, D., Sun, L., Wu, Y., Zou, Y., Liang, C., ... & Li, Y. (2019). Induced expression of VEGFC, ANGPT, and EFNB2 and their receptors characterizes neovascularization in proliferative diabetic retinopathy. Investigative Ophthalmology & Visual Science, 60(13), 4084-4096.

Levy, J., Haye, D., Marziliano, N., Casu, G., Guimiot, F., Dupont, C., ... & Tabet, A. C. (2018). EFNB2 haploinsufficiency causes a syndromic neurodevelopmental disorder. Clinical Genetics, 93(6), 1141-1147.

Zhang, Y., Zhang, R., Ding, X., & Ai, K. (2018). EFNB2 acts as the target of miR-557 to facilitate cell proliferation, migration and invasion in pancreatic ductal adenocarcinoma by bioinformatics analysis and verification. American Journal of Translational Research, 10(11), 3514.

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For research use only. Not intended for any clinical use.

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