DVL3

This gene is a member of a multi-gene family which shares strong similarity with the Drosophila dishevelled gene, dsh. The Drosophila dishevelled gene encodes a cytoplasmic phosphoprotein that regulates cell proliferation. [provided by RefSeq, Jul 2008]

Dishevelled Segment Polarity Protein 3

Involved in the signal transduction pathway mediated by multiple Wnt genes.

Canonical Wnt signaling pathway Source: BHF-UCL
Intracellular signal transduction Source: InterPro
Non-canonical Wnt signaling pathway Source: BHF-UCL
Non-canonical Wnt signaling pathway via JNK cascade Source: BHF-UCL
Planar cell polarity pathway involved in neural tube closure Source: GO_Central
Positive regulation of GTPase activity Source: ParkinsonsUK-UCL
Positive regulation of JUN kinase activity Source: BHF-UCL
Positive regulation of neuron projection arborization Source: ARUK-UCL
Positive regulation of protein phosphorylation Source: BHF-UCL
Positive regulation of transcription, DNA-templated Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Protein stabilization Source: ParkinsonsUK-UCL
Regulation of cellular protein localization Source: ParkinsonsUK-UCL
Response to drug Source: Ensembl
Wnt signaling pathway, planar cell polarity pathway Source: BHF-UCL

Cytoplasm

Robinow syndrome, autosomal dominant 3 (DRS3):
A form of Robinow syndrome, a rare skeletal dysplasia syndrome characterized by dysmorphic features resembling a fetal face, mesomelic limb shortening, genital hypoplasia, renal anomalies, and costovertebral segmentation defects.

Ubiquitinated. Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains.
Phosphorylated by CSNK1D.
Arginine methylation may function as a switch in regulation of function in Wnt signaling.