Rabbit Anti-DVL3 Monoclonal Antibody (EP1991Y) (CBMAB-1016-YC)

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Datasheet

Summary

Host Animal

Rabbit

Specificity

Human, Mouse, Rat

Clone

EP1991Y

Antibody Isotype

IgG

Application

FC, IHC-P, ICC, IF, WB

Basic Information

Immunogen

Synthetic peptide corresponding to residues near the C-terminal of human Dishevelled 3.

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

Dishevelled Segment Polarity Protein 3

Introduction

Dishevelled segment polarity protein 3 (DVL3) is a member of a multi-gene family which shares strong similarity with the Drosophila dishevelled gene, dsh. dsh is a cytoplasmic phosphoprotein that regulates cell proliferation.

Entrez Gene ID

Human	1857
Mouse	13544
Rat	303811

UniProt ID

Human	Q92997
Mouse	Q61062
Rat	D4ADV8

Alternative Names

DRS3

Research Area

Involved in the signal transduction pathway mediated by multiple Wnt genes.

Biological Process

Canonical Wnt signaling pathway Source: BHF-UCL
Intracellular signal transduction Source: InterPro
Non-canonical Wnt signaling pathway Source: BHF-UCL
Non-canonical Wnt signaling pathway via JNK cascade Source: BHF-UCL
Planar cell polarity pathway involved in neural tube closure Source: GO_Central
Positive regulation of GTPase activity Source: ParkinsonsUK-UCL
Positive regulation of JUN kinase activity Source: BHF-UCL
Positive regulation of neuron projection arborization Source: ARUK-UCL
Positive regulation of protein phosphorylation Source: BHF-UCL
Positive regulation of transcription, DNA-templated Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Protein stabilization Source: ParkinsonsUK-UCL
Regulation of cellular protein localization Source: ParkinsonsUK-UCL
Response to drug Source: Ensembl
Wnt signaling pathway, planar cell polarity pathway Source: BHF-UCL

Cellular Location

Cytoplasm

Involvement in disease

Robinow syndrome, autosomal dominant 3 (DRS3):
A form of Robinow syndrome, a rare skeletal dysplasia syndrome characterized by dysmorphic features resembling a fetal face, mesomelic limb shortening, genital hypoplasia, renal anomalies, and costovertebral segmentation defects.

PTM

Ubiquitinated. Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains.
Phosphorylated by CSNK1D.
Arginine methylation may function as a switch in regulation of function in Wnt signaling.

More Infomation

References

Jin, X., Huang, T., Ma, C., Duan, J., Li, R., Zhang, W., & Tian, W. (2021). Protein tyrosine kinase 7‑knockdown inhibits oral squamous cell carcinoma cell viability, proliferation, migration and invasion via downregulating dishevelled segment polarity protein 3 expression. Experimental and Therapeutic Medicine, 22(6), 1-9.

Zheng, X. Y., Cao, M. Z., Ba, Y., Li, Y. F., & Ye, J. L. (2021). LncRNA testis-specific transcript, Y-linked 15 (TTTY15) promotes proliferation, migration and invasion of colorectal cancer cells via regulating miR-29a-3p/DVL3 axis. Cancer Biomarkers, 31(1), 1-11.

Sremac, M., Paic, F., Ravic, K. G., Serman, L., Dujmovic, A. P., Brcic, I., ... & Martic, T. N. (2021). Aberrant expression of SFRP1, SFRP3, DVL2 and DVL3 Wnt signaling pathway components in diffuse gastric carcinoma. Oncology Letters, 22(6), 1-19.

Liao, B., Chen, S., Li, Y., Yang, Z., Yang, Y., Deng, X., & Ke, S. (2021). LncRNA BLACAT1 promotes proliferation, migration and invasion of prostate cancer cells via regulating miR-29a-3p/DVL3 axis. Technology in Cancer Research & Treatment, 20, 1533033820972342.

Li, L., Mao, B., Yan, M., Wu, S., Ge, R., Lian, Q., & Cheng, C. Y. (2019). Planar cell polarity protein Dishevelled 3 (Dvl3) regulates ectoplasmic specialization (ES) dynamics in the testis through changes in cytoskeletal organization. Cell death & disease, 10(3), 1-24.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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