DUSP3

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1. [provided by RefSeq, Jul 2008]

Dual Specificity Phosphatase 3

Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2.

Cellular response to epidermal growth factor stimulus Source: BHF-UCL
Dephosphorylation Source: UniProtKB
Inactivation of MAPK activity Source: UniProtKB
Negative regulation of cell migration Source: BHF-UCL
Negative regulation of chemotaxis Source: BHF-UCL
Negative regulation of epidermal growth factor receptor signaling pathway Source: BHF-UCL
Negative regulation of ERK1 and ERK2 cascade Source: UniProtKB
Negative regulation of JNK cascade Source: UniProtKB
Negative regulation of MAPK cascade Source: UniProtKB
Negative regulation of T cell activation Source: UniProtKB
Negative regulation of T cell receptor signaling pathway Source: UniProtKB
Peptidyl-tyrosine dephosphorylation Source: UniProtKB
Peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity Source: BHF-UCL
Positive regulation of focal adhesion disassembly Source: BHF-UCL
Positive regulation of mitotic cell cycle Source: UniProtKB
Regulation of focal adhesion assembly Source: BHF-UCL

Nucleus