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Mouse Anti-DUSP3 Recombinant Antibody (44) (CBMAB-D1894-YC)


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Summary

Host Animal
Mouse
Specificity
Human, Rat
Clone
44
Antibody Isotype
IgG2a, κ
Application
WB, IHC-P

Basic Information

Immunogen
Ser2-Pro185 of human DUSP3.
Host Species
Mouse
Specificity
Human, Rat
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB0.5-5 µg/ml
IHC-P5-30 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Glycerol & PBS
Preservative
Sodium Azide
Concentration
1 mg/ml
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Dual Specificity Phosphatase 3
Introduction
DUSP3 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1.
Entrez Gene ID
Human1845
Rat498003
UniProt ID
HumanP51452
RatG3V9L3
Alternative Names
Dual Specificity Phosphatase 3; Dual Specificity Protein Phosphatase VHR; Vaccinia Virus Phosphatase VH1-Related; Vaccinia H1-Related Phosphatase; VHR; Serine/Threonine Specific Protein Phosphatase; Dual Specificity Protein Phosphatase 3; EC 3.1.3.16; EC 3.1.3.48;
Research Area
Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2.
Biological Process
Cellular response to epidermal growth factor stimulus Source: BHF-UCL
Dephosphorylation Source: UniProtKB
Inactivation of MAPK activity Source: UniProtKB
Negative regulation of cell migration Source: BHF-UCL
Negative regulation of chemotaxis Source: BHF-UCL
Negative regulation of epidermal growth factor receptor signaling pathway Source: BHF-UCL
Negative regulation of ERK1 and ERK2 cascade Source: UniProtKB
Negative regulation of JNK cascade Source: UniProtKB
Negative regulation of MAPK cascade Source: UniProtKB
Negative regulation of T cell activation Source: UniProtKB
Negative regulation of T cell receptor signaling pathway Source: UniProtKB
Peptidyl-tyrosine dephosphorylation Source: UniProtKB
Peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity Source: BHF-UCL
Positive regulation of focal adhesion disassembly Source: BHF-UCL
Positive regulation of mitotic cell cycle Source: UniProtKB
Regulation of focal adhesion assembly Source: BHF-UCL
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

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