Mouse Anti-DUSP3 Recombinant Antibody (D1898) (V2LY-0425-LY1070)

Name: Mouse Anti-DUSP3 Recombinant Antibody (D1898)
SKU: V2LY-0425-LY1070
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

D1898

Antibody Isotype

IgG1

Application

IHC

Basic Information

Immunogen

E. coli-derived recombinant human VHR (Ser2-Pro185).

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

Application	Note
IHC	8-25 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

Trehalose & PBS

Preservative

None

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

Dual Specificity Phosphatase 3

Entrez Gene ID

1845

UniProt ID

P51452

Research Area

Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2.

Biological Process

Cellular response to epidermal growth factor stimulus Source: BHF-UCL
Dephosphorylation Source: UniProtKB
Inactivation of MAPK activity Source: UniProtKB
Negative regulation of cell migration Source: BHF-UCL
Negative regulation of chemotaxis Source: BHF-UCL
Negative regulation of epidermal growth factor receptor signaling pathway Source: BHF-UCL
Negative regulation of ERK1 and ERK2 cascade Source: UniProtKB
Negative regulation of JNK cascade Source: UniProtKB
Negative regulation of MAPK cascade Source: UniProtKB
Negative regulation of T cell activation Source: UniProtKB
Negative regulation of T cell receptor signaling pathway Source: UniProtKB
Peptidyl-tyrosine dephosphorylation Source: UniProtKB
Peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity Source: BHF-UCL
Positive regulation of focal adhesion disassembly Source: BHF-UCL
Positive regulation of mitotic cell cycle Source: UniProtKB
Regulation of focal adhesion assembly Source: BHF-UCL

Cellular Location

Nucleus

More Infomation

References

Khbouz, B., Rowart, P., Poma, L., Dahlke, E., Bottner, M., Stokes, M., ... & Jouret, F. (2022). The genetic deletion of the Dual Specificity Phosphatase 3 (DUSP3) attenuates kidney damage and inflammation following ischaemia/reperfusion injury in mouse. Acta Physiologica, 234(2), e13735.

Jacques, S., Arjomand, A., Perée, H., Collins, P., Mayer, A., Lavergne, A., ... & Rahmouni, S. (2021). Dual-specificity phosphatase 3 deletion promotes obesity, non-alcoholic steatohepatitis and hepatocellular carcinoma. Scientific reports, 11(1), 1-15.

Kim, B. R., Ha, J., Kang, E., & Cho, S. (2020). Regulation of signal transducer and activator of transcription 3 activation by dual-specificity phosphatase 3. BMB reports, 53(6), 335.

Monteiro, L. F., Ferruzo, P. Y. M., Russo, L. C., Farias, J. O., & Forti, F. L. (2018). DUSP3/VHR: A druggable dual phosphatase for human diseases. Reviews of Physiology, Biochemistry and Pharmacology 176, 1-35.

Chen, Y. R., Chou, H. C., Yang, C. H., Chen, H. Y., Liu, Y. W., Lin, T. Y., ... & Tan, T. H. (2017). Deficiency in VHR/DUSP3, a suppressor of focal adhesion kinase, reveals its role in regulating cell adhesion and migration. Oncogene, 36(47), 6509-6517.

Vandereyken, M. M., Singh, P., Wathieu, C. P., Jacques, S., Zurashvilli, T., Dejager, L., ... & Rahmouni, S. (2017). Dual-specificity phosphatase 3 deletion protects female, but not male, mice from endotoxemia-induced and polymicrobial-induced septic shock. The Journal of Immunology, 199(7), 2515-2527.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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SDS
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