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DLX5

This gene encodes a member of a homeobox transcription factor gene family similiar to the Drosophila distal-less gene. The encoded protein may play a role in bone development and fracture healing. Mutation in this gene, which is located in a tail-to-tail configuration with another member of the family on the long arm of chromosome 7, may be associated with split-hand/split-foot malformation. [provided by RefSeq]
Full Name
distal-less homeobox 5
Function
Transcriptional factor involved in bone development. Acts as an immediate early BMP-responsive transcriptional activator essential for osteoblast differentiation. Stimulates ALPL promoter activity in a RUNX2-independent manner during osteoblast differentiation. Stimulates SP7 promoter activity during osteoblast differentiation. Promotes cell proliferation by up-regulating MYC promoter activity. Involved as a positive regulator of both chondrogenesis and chondrocyte hypertrophy in the endochondral skeleton. Binds to the homeodomain-response element of the ALPL and SP7 promoter. Binds to the MYC promoter. Requires the 5'-TAATTA-3' consensus sequence for DNA-binding.
Biological Process
Anatomical structure formation involved in morphogenesis Source: GO_Central
BMP signaling pathway Source: BHF-UCL
Cell differentiation Source: GO_Central
Cell population proliferation Source: UniProtKB
Cellular response to BMP stimulus Source: BHF-UCL
Embryonic limb morphogenesis Source: Ensembl
Endochondral ossification Source: UniProtKB
Epithelial cell differentiation Source: Ensembl
Face morphogenesis Source: Ensembl
Inner ear morphogenesis Source: Ensembl
Interneuron axon guidance Source: Ensembl
Nervous system development Source: ProtInc
Olfactory bulb interneuron differentiation Source: Ensembl
Olfactory pit development Source: Ensembl
Osteoblast differentiation Source: UniProtKB
Positive regulation of canonical Wnt signaling pathway Source: Ensembl
Positive regulation of epithelial cell proliferation Source: Ensembl
Positive regulation of gene expression Source: Ensembl
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus Source: BHF-UCL
Regulation of transcription by RNA polymerase II Source: GO_Central
Roof of mouth development Source: Ensembl
Skeletal system development Source: ProtInc
Cellular Location
Nucleus
Involvement in disease
Split-hand/foot malformation 1 with sensorineural hearing loss, autosomal recessive (SHFM1D):
A disease characterized by the association of split-hand/foot malformation with deafness. Split-hand/foot malformation is a limb malformation involving the central rays of the autopod and presenting with syndactyly, median clefts of the hands and feet, and aplasia and/or hypoplasia of the phalanges, metacarpals, and metatarsals. Some patients have been found to have mental retardation, ectodermal and craniofacial findings, and orofacial clefting.
PTM
Phosphorylated. Phosphorylation of Ser-34 and Ser-217 by MAPK14 enhances its transcriptional activity. Phosphorylation by CaMK2 increases its protein stability (By similarity).

Anti-DLX5 antibodies

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Target: DLX5
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4C6
Application*: E, IF, WB
Target: DLX5
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3B11
Application*: E, IF, WB
Target: DLX5
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 4F5
Application*: E, WB
Target: DLX5
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 2B6
Application*: E
Target: DLX5
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 9G371
Application*: E
Target: DLX5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYCD-313
Application*: IC, IF
Target: DLX5
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 4B7
Application*: E, WB
Target: DLX5
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3F5
Application*: E
Target: DLX5
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 1B7
Application*: E
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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