DLX2

Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 2. [provided by RefSeq]

distal-less homeobox 2

Acts as a transcriptional activator. Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina. Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis.

Brain development Source: ProtInc
Branching morphogenesis of a nerve Source: Ensembl
Cartilage development Source: Ensembl
Cell differentiation Source: GO_Central
Cerebral cortex GABAergic interneuron fate commitment Source: Ensembl
Embryonic cranial skeleton morphogenesis Source: Ensembl
Forebrain neuron differentiation Source: Ensembl
Hippocampus development Source: Ensembl
Negative regulation of Notch signaling pathway Source: Ensembl
Negative regulation of oligodendrocyte differentiation Source: Ensembl
Negative regulation of photoreceptor cell differentiation Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: GO_Central
Odontogenesis of dentin-containing tooth Source: Ensembl
Olfactory bulb development Source: Ensembl
Positive regulation of amacrine cell differentiation Source: UniProtKB
Positive regulation of cell differentiation Source: UniProtKB
Proximal/distal pattern formation Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Subpallium development Source: Ensembl

Nucleus