Mouse Anti-DLX2 Recombinant Antibody (3G6) (CBMAB-A2270-LY)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

3G6

Antibody Isotype

IgG2a, κ

Application

WB, ELISA

Basic Information

Immunogen

DLX2 (NP_004396, 1 a.a. ~ 124 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

distal-less homeobox 2

Introduction

Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 2. [provided by RefSeq]

Entrez Gene ID

1746

Alternative Names

TES-1; TES1

Function

Acts as a transcriptional activator. Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina. Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis.

Biological Process

Brain development Source: ProtInc
Branching morphogenesis of a nerve Source: Ensembl
Cartilage development Source: Ensembl
Cell differentiation Source: GO_Central
Cerebral cortex GABAergic interneuron fate commitment Source: Ensembl
Embryonic cranial skeleton morphogenesis Source: Ensembl
Forebrain neuron differentiation Source: Ensembl
Hippocampus development Source: Ensembl
Negative regulation of Notch signaling pathway Source: Ensembl
Negative regulation of oligodendrocyte differentiation Source: Ensembl
Negative regulation of photoreceptor cell differentiation Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: GO_Central
Odontogenesis of dentin-containing tooth Source: Ensembl
Olfactory bulb development Source: Ensembl
Positive regulation of amacrine cell differentiation Source: UniProtKB
Positive regulation of cell differentiation Source: UniProtKB
Proximal/distal pattern formation Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Subpallium development Source: Ensembl

Cellular Location

Nucleus

More Infomation

References

Wang, Z., Wang, D., Guo, S., Zhuo, Q., Jiang, D., & Yu, Z. (2022). Long noncoding RNA distal-less homeobox 2 antisense 1 restrains inflammatory response and apoptosis of periodontal ligament cells by binding with microRNA-330-3p to regulate Ro60, Y RNA binding protein. Archives of oral biology, 133, 105298.

Yang, C., Chen, Y., & Yuan, Y. (2021). Bone Marrow Mesenchymal Stem Cells Transfected with Distal-Less Homeobox 2 Gene Promote Articular Cartilage Repair after Injury.

Dai, Q., Deng, J., Zhou, J., Wang, Z., Yuan, X. F., Pan, S., & Zhang, H. B. (2020). Long non-coding RNA TUG1 promotes cell progression in hepatocellular carcinoma via regulating miR-216b-5p/DLX2 axis. Cancer cell international, 20(1), 1-13.

Zeng, X., Wang, Y., Dong, Q., Ma, M. X., & Liu, X. D. (2020). DLX2 activates Wnt1 transcription and mediates Wnt/β-catenin signal to promote osteogenic differentiation of hBMSCs. Gene, 744, 144564.

Lee, S. Y., Ju, M. K., Jeon, H. M., Lee, Y. J., Kim, C. H., Park, H. G., ... & Kang, H. S. (2019). Reactive oxygen species induce epithelial‑mesenchymal transition, glycolytic switch, and mitochondrial repression through the Dlx‑2/Snail signaling pathways in MCF‑7 cells. Molecular medicine reports, 20(3), 2339-2346.

Dai, J., Si, J., Ouyang, N., Zhang, J., Wu, D., Wang, X., & Shen, G. (2017). Dental and periodontal phenotypes of Dlx2 overexpression in mice. Molecular Medicine Reports, 15(5), 2443-2450.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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