DCT

DCT (Dopachrome Tautomerase) is a Protein Coding gene. Diseases associated with DCT include Microphthalmia and Hermansky-Pudlak Syndrome 3. Among its related pathways are Phenylalanine metabolism and Neural Crest Differentiation. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and dopachrome isomerase activity. An important paralog of this gene is TYRP1.

Full Name

Dopachrome Tautomerase

Function

Catalyzes the conversion of L-dopachrome into 5,6-dihydroxyindole-2-carboxylic acid (DHICA).

Biological Process

Cell development Source: Ensembl
Developmental pigmentation Source: GO_Central
Epidermis development Source: ProtInc
Melanin biosynthetic process Source: Reactome
Melanin biosynthetic process from tyrosine Source: UniProtKB
Positive regulation of neuroblast proliferation Source: GO_Central
Response to blue light Source: UniProtKB
Ventricular zone neuroblast division Source: GO_Central

Cellular Location

Melanosome membrane; Melanosome. Proper trafficking to melanosome is regulated by SGSM2, ANKRD27, RAB9A, RAB32 and RAB38.

Topology

Lumenal, melanosome: 24-472
Helical: 473-493
Cytoplasmic: 494-519

PTM

Glycosylated.

Anti-DCT antibodies

Rabbit Anti-DCT Recombinant Antibody (EG935) (CBMAB-EN1107-LY)

Datasheet

SDS

Target: DCT

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse

Clone: EG935

Application*: WB: 1:500~1:1000 IF: 1:100~1:500 ELISA: 1:40000

Mouse Anti-DCT Recombinant Antibody (CBYJT-1184) (CBMAB-T0198-YJ)

Datasheet

SDS

Target: DCT

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBYJT-1184

Application*: WB, IC, P, C, E

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)