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Mouse Anti-DCT Recombinant Antibody (CBYJT-1184) (CBMAB-T0198-YJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-1184
Antibody Isotype
IgG
Application
WB, ICC, IHC-P, IHC-Fr, ELISA

Basic Information

Immunogen
Dopachrome Tautomerase
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4, 50% Glycerol
Preservative
0.02% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Dopachrome Tautomerase
Introduction
DCT (Dopachrome Tautomerase) is a Protein Coding gene. Diseases related to DCT include Microphthalmia and Hermansky-Pudlak Syndrome 3. Among its related pathways are Phenylalanine metabolism and Neural Crest Differentiation. Gene Ontology (GO) annotations related to DCT include oxidoreductase activity and dopachrome isomerase activity. An important paralog of DCT is TYRP1.
Entrez Gene ID
1638
UniProt ID
P40126
Alternative Names
Dopachrome Tautomerase; L-Dopachrome Delta-Isomerase; Dopachrome Delta-Isomerase; Tyrosine-Related Protein 2; L-Dopachrome Isomerase; EC 5.3.3.12; TYRP2; TRP-2
Function
Catalyzes the conversion of L-dopachrome into 5,6-dihydroxyindole-2-carboxylic acid (DHICA).
Biological Process
Cell development Source: Ensembl
Developmental pigmentation Source: GO_Central
Epidermis development Source: ProtInc
Melanin biosynthetic process Source: Reactome
Melanin biosynthetic process from tyrosine Source: UniProtKB
Positive regulation of neuroblast proliferation Source: GO_Central
Response to blue light Source: UniProtKB
Ventricular zone neuroblast division Source: GO_Central
Cellular Location
Melanosome membrane; Melanosome. Proper trafficking to melanosome is regulated by SGSM2, ANKRD27, RAB9A, RAB32 and RAB38.
Topology
Lumenal, melanosome: 24-472
Helical: 473-493
Cytoplasmic: 494-519
PTM
Glycosylated.
More Infomation

Volk, A. E., Hedergott, A., Preising, M., Rading, S., Fricke, J., Herkenrath, P., ... & Kubisch, C. (2021). Biallelic mutations in L-dopachrome tautomerase (DCT) cause infantile nystagmus and oculocutaneous albinism. Human Genetics, 140(8), 1157-1168.

Pennamen, P., Tingaud-Sequeira, A., Gazova, I., Keighren, M., McKie, L., Marlin, S., ... & Arveiler, B. (2021). Dopachrome tautomerase variants in patients with oculocutaneous albinism. Genetics in Medicine, 23(3), 479-487.

Rosani, U., Domeneghetti, S., Maso, L., Wegner, K. M., & Venier, P. (2019). An evolutionary perspective of dopachrome tautomerase enzymes in metazoans. Genes, 10(7), 495.

Salinas‑Santander, M., Trevino, V., de la Rosa‑Moreno, E., Verduzco‑Garza, B., Sánchez‑Domínguez, C. N., Cantú‑Salinas, C., ... & Ortiz‑López, R. (2018). CAPN3, DCT, MLANA and TYRP1 are overexpressed in skin of vitiligo vulgaris Mexican patients. Experimental and Therapeutic Medicine, 15(3), 2804-2811.

Dardente, H., & Lomet, D. (2018). Photoperiod and thyroid hormone regulate expression of l‐dopachrome tautomerase (Dct), a melanocyte stem‐cell marker, in tanycytes of the ovine hypothalamus. Journal of Neuroendocrinology, 30(9), e12640.

Sultana, H., Seo, D., Choi, N. R., Bhuiyan, M. S. A., Lee, S. H., Heo, K. N., & Lee, J. H. (2018). Identification of polymorphisms in MITF and DCT genes and their associations with plumage colors in Asian duck breeds. Asian-Australasian journal of animal sciences, 31(2), 180.

Aksoy, P., & Meneses, P. I. (2017). The role of DCT in HPV16 infection of HaCaTs. PLoS One, 12(1), e0170158.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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