DBI

DBI is diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors loca

Full Name

Diazepam Binding Inhibitor, Acyl-CoA Binding Protein

Function

Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor.

Biological Process

Acyl-CoA metabolic process Source: Reactome
Negative regulation of protein lipidation Source: UniProtKB
Phosphatidylcholine acyl-chain remodeling Source: UniProtKB
Positive regulation of CoA-transferase activity Source: UniProtKB
Positive regulation of phospholipid transport Source: UniProtKB

Cellular Location

Golgi apparatus; Endoplasmic reticulum. Golgi localization is dependent on ligand binding (PubMed:17953517).

Anti-DBI antibodies

Mouse Anti-DBI Recombinant Antibody (20B10) (CBMAB-D0295-YC)

Datasheet

SDS

Target: DBI

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 20B10

Application*: IP, E

Mouse Anti-DBI Recombinant Antibody (10K186) (CBMAB-D0294-YC)

Datasheet

SDS

Target: DBI

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 10K186

Application*: E, C, IP, WB

Mouse Anti-DBI Recombinant Antibody (27C9) (CBMAB-D0296-YC)

Datasheet

SDS

Target: DBI

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 27C9

Application*: E, WB, IH, IP

Mouse Anti-DBI Recombinant Antibody (CBFYE-0351) (CBMAB-E0645-FY)

Datasheet

SDS

Target: DBI

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBFYE-0351

Application*: E, P, IP, WB

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)