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Mouse Anti-DBI Recombinant Antibody (20B10) (CBMAB-D0295-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
20B10
Antibody Isotype
IgG1, κ
Application
IP, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Diazepam Binding Inhibitor, Acyl-CoA Binding Protein
Introduction
DBI is a diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor is also known to mediate the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent adrenal steroidogenesis.
Entrez Gene ID
1622
UniProt ID
P07108
Alternative Names
Diazepam Binding Inhibitor, Acyl-CoA Binding Protein; Endozepine; Diazepam Binding Inhibitor (GABA Receptor Modulator, Acyl-Coenzyme A Binding Protein); Diazepam-Binding Inhibitor; ACBP; EP; Diazepam Binding Inhibitor (GABA Receptor Modulator, Acyl-CoA Binding Protein); Cholecystokinin-Releasing Peptide, Trypsin-Sensitive;
Function
Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor.
Biological Process
Acyl-CoA metabolic process Source: Reactome
Negative regulation of protein lipidation Source: UniProtKB
Phosphatidylcholine acyl-chain remodeling Source: UniProtKB
Positive regulation of CoA-transferase activity Source: UniProtKB
Positive regulation of phospholipid transport Source: UniProtKB
Cellular Location
Golgi apparatus; Endoplasmic reticulum. Golgi localization is dependent on ligand binding (PubMed:17953517).
More Infomation

Joseph, A., Chen, H., Anagnostopoulos, G., Montégut, L., Lafarge, A., Motiño, O., ... & Kroemer, G. (2021). Effects of acyl-coenzyme A binding protein (ACBP)/diazepam-binding inhibitor (DBI) on body mass index. Cell death & disease, 12(6), 1-14.

Thomas, A. M., Asnicar, F., Kroemer, G., & Segata, N. (2021). Genes Encoding Microbial Acyl Coenzyme A Binding Protein/Diazepam-Binding Inhibitor Orthologs Are Rare in the Human Gut Microbiome and Show No Links to Obesity. Applied and environmental microbiology, 87(12), e00471-21.

Mamoor, S. (2021). Over-expression of diazepam binding inhibitor, acyl-CoA binding protein in human endometrial cancer.

Alquier, T., Christian-Hinman, C. A., Alfonso, J., & Færgeman, N. J. (2021). From benzodiazepines to fatty acids and beyond: revisiting the role of ACBP/DBI. Trends in Endocrinology & Metabolism, 32(11), 890-903.

Joseph, A., Moriceau, S., Sica, V., Anagnostopoulos, G., Pol, J., Martins, I., ... & Kroemer, G. (2020). Metabolic and psychiatric effects of acyl coenzyme A binding protein (ACBP)/diazepam binding inhibitor (DBI). Cell death & disease, 11(7), 1-10.

Charmpilas, N., Ruckenstuhl, C., Sica, V., Büttner, S., Habernig, L., Dichtinger, S., ... & Kroemer, G. (2020). Acyl-CoA-binding protein (ACBP): a phylogenetically conserved appetite stimulator. Cell death & disease, 11(1), 1-10.

Bravo-San Pedro, J. M., Sica, V., Martins, I., Anagnostopoulos, G., Maiuri, C., & Kroemer, G. (2019). Cell-autonomous, paracrine and neuroendocrine feedback regulation of autophagy by DBI/ACBP (diazepam binding inhibitor, acyl-CoA binding protein): the obesity factor. Autophagy, 15(11), 2036-2038.

Bravo-San Pedro, J. M., Sica, V., Madeo, F., & Kroemer, G. (2019). Acyl-CoA-binding protein (ACBP): the elusive ‘hunger factor'linking autophagy to food intake. Cell Stress, 3(10), 312.

Bravo-San Pedro, J. M., Sica, V., Martins, I., Pol, J., Loos, F., Maiuri, M. C., ... & Kroemer, G. (2019). Acyl-CoA-binding protein is a lipogenic factor that triggers food intake and obesity. Cell metabolism, 30(4), 754-767.

Duman, C., Yaqubi, K., Hoffmann, A., Acikgöz, A. A., Korshunov, A., Bendszus, M., ... & Alfonso, J. (2019). Acyl-CoA-binding protein drives glioblastoma tumorigenesis by sustaining fatty acid oxidation. Cell metabolism, 30(2), 274-289.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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