CTSS

CTSS (Cathepsin S) is a Protein Coding gene. Diseases associated with CTSS include Cercarial Dermatitis and Mandibular Cancer. Among its related pathways are Bacterial infections in CF airways and Innate Immune System. Gene Ontology (GO) annotations related to this gene include peptidase activity and cysteine-type peptidase activity. An important paralog of this gene is CTSK.

Cathepsin S

Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules and MHC class II antigen presentation (PubMed:30612035).

The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L.

Adaptive immune response Source: UniProtKB
Antigen processing and presentation Source: UniProtKB
Antigen processing and presentation of exogenous peptide antigen via MHC class II Source: UniProtKB
Antigen processing and presentation of peptide antigen Source: CACAO
Basement membrane disassembly Source: BHF-UCL
Cellular response to thyroid hormone stimulus Source: UniProtKB
Collagen catabolic process Source: BHF-UCL
Extracellular matrix disassembly Source: Reactome
Immune response Source: GO_Central
Neutrophil degranulation Source: Reactome
Positive regulation of cation channel activity Source: CACAO
Protein processing Source: CACAO
Proteolysis Source: CAFA
Proteolysis involved in cellular protein catabolic process Source: BHF-UCL
Response to acidic pH Source: CACAO
Toll-like receptor signaling pathway Source: Reactome

Secreted; Lysosome; Phagosome