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Rat Anti-CTSS Recombinant Antibody (14L80) (CBMAB-C3183-LY)


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Summary

Host Animal
Rat
Specificity
Human
Clone
14L80
Antibody Isotype
IgG2
Application
WB

Basic Information

Immunogen
Recombinant protein corresponding to human Cathepsin S
Specificity
Human
Antibody Isotype
IgG2
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Concentration
0.5 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Cathepsin S
Introduction
CTSS (Cathepsin S) is a Protein Coding gene. Diseases associated with CTSS include Cercarial Dermatitis and Mandibular Cancer. Among its related pathways are Bacterial infections in CF airways and Innate Immune System. Gene Ontology (GO) annotations related to this gene include peptidase activity and cysteine-type peptidase activity. An important paralog of this gene is CTSK.
Entrez Gene ID
1520
UniProt ID
P25774
Alternative Names
Cathepsin S; EC 3.4.22.27; EC 3.4.22;
Function
Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules and MHC class II antigen presentation (PubMed:30612035).

The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L.
Biological Process
Adaptive immune response Source: UniProtKB
Antigen processing and presentation Source: UniProtKB
Antigen processing and presentation of exogenous peptide antigen via MHC class II Source: UniProtKB
Antigen processing and presentation of peptide antigen Source: CACAO
Basement membrane disassembly Source: BHF-UCL
Cellular response to thyroid hormone stimulus Source: UniProtKB
Collagen catabolic process Source: BHF-UCL
Extracellular matrix disassembly Source: Reactome
Immune response Source: GO_Central
Neutrophil degranulation Source: Reactome
Positive regulation of cation channel activity Source: CACAO
Protein processing Source: CACAO
Proteolysis Source: CAFA
Proteolysis involved in cellular protein catabolic process Source: BHF-UCL
Response to acidic pH Source: CACAO
Toll-like receptor signaling pathway Source: Reactome
Cellular Location
Secreted; Lysosome; Phagosome
More Infomation

Yoo, Y., Choi, E., Kim, Y., Cha, Y., Um, E., Kim, Y., ... & Lee, Y. S. (2022). Therapeutic potential of targeting cathepsin S in pulmonary fibrosis. Biomedicine & Pharmacotherapy, 145, 112245.

Bararia, D., Hildebrand, J. A., Stolz, S., Haebe, S., Alig, S., Trevisani, C. P., ... & Weigert, O. (2020). Cathepsin S alterations induce a tumor-promoting immune microenvironment in follicular lymphoma. Cell reports, 31(5), 107522.

Brown, R., Nath, S., Lora, A., Samaha, G., Elgamal, Z., Kaiser, R., ... & Geraghty, P. (2020). Cathepsin S: investigating an old player in lung disease pathogenesis, comorbidities, and potential therapeutics. Respiratory Research, 21(1), 1-17.

Ni, H., Xu, S., Chen, H., & Dai, Q. (2020). Nicotine modulates CTSS (cathepsin S) synthesis and secretion through regulating the autophagy-lysosomal machinery in atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology, 40(9), 2054-2069.

Lai, C. H., Chang, J. Y., Wang, K. C., Lee, F. T., Wu, H. L., & Cheng, T. L. (2020). Pharmacological inhibition of cathepsin S suppresses abdominal aortic aneurysm in mice. European Journal of Vascular and Endovascular Surgery, 59(6), 990-999.

Doherty, D. F., Nath, S., Poon, J., Foronjy, R. F., Ohlmeyer, M., Dabo, A. J., ... & Geraghty, P. (2019). Protein phosphatase 2A reduces cigarette smoke–induced cathepsin S and loss of lung function. American journal of respiratory and critical care medicine, 200(1), 51-62.

Kim, S., Jin, H., Seo, H. R., Lee, H. J., & Lee, Y. S. (2019). Regulating BRCA1 protein stability by cathepsin S-mediated ubiquitin degradation. Cell Death & Differentiation, 26(5), 812-825.

Wilkinson, R. D., Burden, R. E., McDowell, S. H., McArt, D. G., McQuaid, S., Bingham, V., ... & Scott, C. J. (2019). A novel role for cathepsin S as a potential biomarker in triple negative breast cancer. Journal of Oncology, 2019.

Edman, M. C., Janga, S. R., Meng, Z., Bechtold, M., Chen, A. F., Kim, C., ... & Hamm-Alvarez, S. F. (2018). Increased Cathepsin S activity associated with decreased protease inhibitory capacity contributes to altered tear proteins in Sjögren’s Syndrome patients. Scientific reports, 8(1), 1-12.

Tan, J., Qian, X., Song, B., An, X., Cai, T., Zuo, Z., ... & Li, H. (2018). Integrated bioinformatics analysis reveals that the expression of cathepsin S is associated with lymph node metastasis and poor prognosis in papillary thyroid cancer. Oncology reports, 40(1), 111-122.

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For research use only. Not intended for any clinical use.

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