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CTSK

CTSK (Cathepsin K) is a Protein Coding gene. Diseases associated with CTSK include Pycnodysostosis and Endosteal Hyperostosis, Autosomal Dominant. Among its related pathways are RANK Signaling in Osteoclasts and Innate Immune System. Gene Ontology (GO) annotations related to this gene include cysteine-type endopeptidase activity and collagen binding. An important paralog of this gene is CTSS.

Full Name

Cathepsin K

Function

Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (PubMed:11082042).

Biological Process

Autophagy of mitochondrion Source: ParkinsonsUK-UCL
Collagen catabolic process Source: BHF-UCL
Extracellular matrix disassembly Source: Reactome
Immune response Source: GO_Central
Proteolysis Source: ProtInc
Proteolysis involved in cellular protein catabolic process Source: UniProtKB
Regulation of keratinocyte differentiation Source: Reactome
Thyroid hormone generation Source: UniProtKB
Toll-like receptor signaling pathway Source: Reactome

Cellular Location

Lysosome; Apical cell membrane; Secreted. Localizes to the lumen of thyroid follicles and to the apical membrane of thyroid epithelial cells.

Involvement in disease

Pycnodysostosis (PKND):
A rare autosomal recessive bone disorder characterized by deformity of the skull, maxilla and phalanges, osteosclerosis, and fragility of bone.

Anti-CTSK antibodies

Mouse Anti-CTSK Recombinant Antibody (CBXC-0621) (CBMAB-C3115-CQ)

SDS

Target: CTSK

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBXC-0621

Application*: WB

Mouse Anti-CTSK Recombinant Antibody (CBXC-0620) (CBMAB-C3116-CQ)

SDS

Target: CTSK

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBXC-0620

Application*: E, IH, WB

Mouse Anti-CTSK Recombinant Antibody (CBWJC-3427) (CBMAB-C4651WJ)

SDS

Target: CTSK

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBWJC-3427

Application*: WB, IC, P, IH-F, E, IP, IF, F

Mouse Anti-CTSK Recombinant Antibody (2F1) (CBMAB-C0882-LY)

SDS

Target: CTSK

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 2F1

Application*: E, C, WB

Mouse Anti-CTSK Recombinant Antibody (V2-186962) (CBMAB-C6698-LY)

SDS

Target: CTSK

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: V2-186962

Application*: C, WB

Mouse Anti-CTSK Recombinant Antibody (10C464) (CBMAB-C3137-CN)

SDS

Target: CTSK

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 10C464

Application*: E, IH, WB

Mouse Anti-CTSK Recombinant Antibody (CBCNC-483) (CBMAB-C3140-CN)

SDS

Target: CTSK

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBCNC-483

Application*: WB

Mouse Anti-CTSK Recombinant Antibody (CBCNC-484) (CBMAB-C3141-CN)

SDS

Target: CTSK

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBCNC-484

Application*: E, P, WB

Mouse Anti-CTSK Recombinant Antibody (CBCNC-486) (CBMAB-C3143-CN)

SDS

Target: CTSK

Host: Mouse

Specificity: Human

Clone: CBCNC-486

Application*: WB, ICC, P, IH-F, E

Mouse Anti-CTSK Recombinant Antibody (CBLC201-LY) (CBMAB-C11328-LY)

SDS

Target: CTSK

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBLC201-LY

Application*: WB, E, P, F

Mouse Anti-CTSK Recombinant Antibody (CBLC202-LY) (CBMAB-C11329-LY)

SDS

Target: CTSK

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBLC202-LY

Application*: E, WB, P

Mouse Anti-CTSK Recombinant Antibody (CAP599) (CBMAB-AP1782LY)

SDS

Target: CTSK

Host: Mouse

Antibody Isotype: IgG

Specificity: Monkey

Clone: CAP599

Application*: ICC, IHC, IP, WB

Mouse Anti-CTSK Recombinant Antibody (CAP600) (CBMAB-AP1783LY)

SDS

Target: CTSK

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Pig, Rat

Clone: CAP600

Application*: ICC, IHC, IP, WB

Mouse Anti-CTSK (AA 220-329) Recombinant Antibody (CBFYC-2452) (CBMAB-C2525-FY)

SDS

Target: CTSK

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBFYC-2452

Application*: E

Mouse Anti-CTSK Recombinant Antibody (CBXC-0619) (CBMAB-C5054-CQ)

SDS

Target: CTSK

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBXC-0619

Application*: E, P, WB

Mouse Anti-CTSK Recombinant Antibody (CBCNC-485) (CBMAB-C3142-CN)

SDS

Target: CTSK

Host: Mouse

Antibody Isotype: IgG

Specificity: Monkey

Clone: CBCNC-485

Application*: E, WB

Mouse Anti-CTSK Recombinant Antibody (3F9) (CBMAB-1491-CN)

SDS

Target: CTSK

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 3F9

Application*: E, F, P, IP, WB

Mouse Anti-CTSK Recombinant Antibody (CBLNC-141) (CBMAB-1492-CN)

SDS

Target: CTSK

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBLNC-141

Application*: E, WB, F, IF, P

Rabbit Anti-CTSK Recombinant Antibody (EP9403) (CBMAB-1493-CN)

SDS

Target: CTSK

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: EP9403

Application*: WB

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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