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Mouse Anti-CTSK Recombinant Antibody (CBLNC-141) (CBMAB-1492-CN)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBLNC-141
Antibody Isotype
IgG2a
Application
ELISA, WB, FC, IF, IHC-P

Basic Information

Immunogen
Recombinant fragment with tag: KCRGYREIPE GNEKALKRAV ARVGPVSVAI DASLTSFQFY SKGVYYDESC NSDNLNHAVL AVGYGIQKGN KHWIIKNSWG ENWGNKGYIL MARNKNNACG IANLASFPKM, corresponding to aa. 220-331 of Human Cathepsin K.
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cathepsin K
Introduction
The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. The protein may play an important role in extracellular matrix degradation.
Entrez Gene ID
1513
UniProt ID
P43235
Alternative Names
CTSO; PKND; PYCD; CTS02; CTSO1; CTSO2
Function
Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (PubMed:11082042).
Biological Process
Autophagy of mitochondrion Source: ParkinsonsUK-UCL
Collagen catabolic process Source: BHF-UCL
Extracellular matrix disassembly Source: Reactome
Immune response Source: GO_Central
Proteolysis Source: ProtInc
Proteolysis involved in cellular protein catabolic process Source: UniProtKB
Regulation of keratinocyte differentiation Source: Reactome
Thyroid hormone generation Source: UniProtKB
Toll-like receptor signaling pathway Source: Reactome
Cellular Location
Lysosome; Apical cell membrane; Secreted. Localizes to the lumen of thyroid follicles and to the apical membrane of thyroid epithelial cells.
Involvement in disease
Pycnodysostosis (PKND):
A rare autosomal recessive bone disorder characterized by deformity of the skull, maxilla and phalanges, osteosclerosis, and fragility of bone.
More Infomation

Heo, S. C., Kim, Y. N., Choi, Y., Joo, J. Y., Hwang, J. J., Bae, M. K., & Kim, H. J. (2021). Elevated expression of cathepsin K in periodontal ligament fibroblast by inflammatory cytokines accelerates osteoclastogenesis via paracrine mechanism in periodontal disease. International Journal of Molecular Sciences, 22(2), 695.

Zhang, W., Dong, Z., Li, D., Li, B., Liu, Y., Zheng, X., ... & Xue, Y. (2021). Cathepsin K deficiency promotes alveolar bone regeneration by promoting jaw bone marrow mesenchymal stem cells proliferation and differentiation via glycolysis pathway. Cell proliferation, 54(7), e13058.

Dauth, S., Rakov, H., Sîrbulescu, R. F., Ilieş, I., Weber, J., Batbajar Dugershaw, B., ... & Brix, K. (2020). Function of Cathepsin K in the central nervous system of male mice is independent of its role in the thyroid gland. Cellular and Molecular Neurobiology, 40(5), 695-710.

Feng, H., Xing, W., Han, Y., Sun, J., Kong, M., Gao, B., ... & Zou, W. (2020). Tendon-derived cathepsin K–expressing progenitor cells activate Hedgehog signaling to drive heterotopic ossification. The Journal of clinical investigation, 130(12), 6354-6365.

Li, R., Zhou, R., Wang, H., Li, W., Pan, M., Yao, X., ... & Zhao, L. (2019). Gut microbiota-stimulated cathepsin K secretion mediates TLR4-dependent M2 macrophage polarization and promotes tumor metastasis in colorectal cancer. Cell Death & Differentiation, 26(11), 2447-2463.

Pang, M., Rodríguez‐Gonzalez, M., Hernandez, M., Recinos, C. C., Seldeen, K. L., & Troen, B. R. (2019). AP‐1 and Mitf interact with NFATc1 to stimulate cathepsin K promoter activity in osteoclast precursors. Journal of cellular biochemistry, 120(8), 12382-12392.

Lotinun, S., Ishihara, Y., Nagano, K., Kiviranta, R., Carpentier, V. T., Neff, L., ... & Baron, R. (2019). Cathepsin K–deficient osteocytes prevent lactation-induced bone loss and parathyroid hormone suppression. The Journal of clinical investigation, 129(8), 3058-3071.

Leusink, F. K., Koudounarakis, E., Frank, M. H., Koole, R., van Diest, P. J., & Willems, S. M. (2018). Cathepsin K associates with lymph node metastasis and poor prognosis in oral squamous cell carcinoma. Bmc Cancer, 18(1), 1-9.

Fan, X., Wang, C., Song, X., Liu, H., Li, X., & Zhang, Y. (2018). Elevated Cathepsin K potentiates metastasis of epithelial ovarian cancer. Histology and Histopathology, 33(7), 673-680.

Walia, B., Lingenheld, E., Duong, L., Sanjay, A., & Drissi, H. (2018). A novel role for cathepsin K in periosteal osteoclast precursors during fracture repair. Annals of the New York Academy of Sciences, 1415(1), 57-68.

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For research use only. Not intended for any clinical use.

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