CORT

The product of this gene is a neuropeptide with strong structural similarity to somatostatin. It binds to all known somatostatin receptors, and shares many pharmacological and functional properties with somatostatin, including the depression of neuronal activity. However, it also has many properties distinct from somatostatin, such as induction of slow-wave sleep, apparently by antagonism of the excitatory effects of acetylcholine on the cortex, reduction of locomotor activity, and activation of cation selective currents not responsive to somatostatin. [provided by RefSeq]

cortistatin

Binds to all human somatostatin receptor (SSTR) subtypes. It also inhibits cAMP production induced by forskolin through SSTRs.

Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: UniProtKB
Chemical synaptic transmission Source: UniProtKB
G protein-coupled receptor signaling pathway Source: Reactome
Replication fork processing Source: GO_Central
Resolution of meiotic recombination intermediates Source: GO_Central

Secreted