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Mouse Anti-CORT Recombinant Antibody (8G10) (CBMAB-1419-CN)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
8G10
Antibody Isotype
IgG2b
Application
ELISA, WB

Basic Information

Immunogen
CORT (NP_001293.2, aa. 1-155) full-length recombinant protein with GST tag.
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
1x PBS,  pH 7.4
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
Localized in aa. 1-155

Target

Full Name
cortistatin
Introduction
This gene encodes a neuropeptide that is structurally similar to somatostatin. It binds to all known somatostatin receptors, and shares many pharmacological and functional properties with somatostatin, including the depression of neuronal activity. It also has many properties distinct from somatostatin, such as induction of slow-wave sleep, apparently by antagonism of the excitatory effects of acetylcholine on the cortex, reduction of locomotor activity, and activation of cation selective currents not responsive to somatostatin.
Entrez Gene ID
1325
UniProt ID
O00230
Alternative Names
CST-14; CST-17; CST-29
Function
Binds to all human somatostatin receptor (SSTR) subtypes. It also inhibits cAMP production induced by forskolin through SSTRs.
Biological Process
Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: UniProtKB
Chemical synaptic transmission Source: UniProtKB
G protein-coupled receptor signaling pathway Source: Reactome
Replication fork processing Source: GO_Central
Resolution of meiotic recombination intermediates Source: GO_Central
Cellular Location
Secreted
More Infomation

Valente, R., Alves, L. Q., Nabais, M., Alves, F., Sousa-Pinto, I., Ruivo, R., & Castro, L. F. C. (2021). Convergent Cortistatin losses parallel modifications in circadian rhythmicity and energy homeostasis in Cetacea and other mammalian lineages. Genomics, 113(1), 1064-1070.

Barriga, M., Benitez, R., Robledo, G., Caro, M., O’Valle, F., Campos-Salinas, J., & Delgado, M. (2021). Neuropeptide Cortistatin Regulates Dermal and Pulmonary Fibrosis in an Experimental Model of Systemic Sclerosis. Neuroendocrinology.

Gomez, J. P., Sáez-Mart, P., Jiménez-Vacas, J. M., Pedraza-Arévalo, S., Enrique, G. G., León-González, A. J., ... & Luque, R. M. (2021, May). Potential therapeutic role of somatostatin and cortistatin in prostate cancer. In Endocrine Abstracts (Vol. 73). Bioscientifica.

Chen, W., Liang, J., Fu, Y., Jin, Y., Yan, R., Chi, J., ... & Yin, X. (2020). Cardioprotection of cortistatin against isoproterenol-induced myocardial injury in rats. Annals of Translational Medicine, 8(6).

Qiu, C., Li, J., Luo, D., Chen, X., Qu, R., Liu, T., ... & Liu, Y. (2020). Cortistatin protects against inflammatory airway diseases through curbing CCL2 and antagonizing NF-κB signaling pathway. Biochemical and Biophysical Research Communications, 531(4), 595-601.

Maynard, K. R., Kardian, A., Hill, J. L., Mai, Y., Barry, B., Hallock, H. L., ... & Martinowich, K. (2020). TrkB signaling influences gene expression in cortistatin-expressing interneurons. Eneuro, 7(1).

Valente, R., Alves, L. Q., Nabais, M., Alves, F., Sousa-Pinto, I., Ruivo, R., & Castro, L. F. C. (2020). Differential Cetacea Circadian Rhythmicity is associated with the molecular erosion of Cortistatin. bioRxiv.

Hill, J. L., Jimenez, D. V., Mai, Y., Ren, M., Hallock, H. L., Maynard, K. R., ... & Martinowich, K. (2019). Cortistatin-expressing interneurons require TrkB signaling to suppress neural hyper-excitability. Brain Structure and Function, 224(1), 471-483.

Ibáñez-Costa, A., Luque, R. M., & Castaño, J. P. (2017). Cortistatin: a new link between the growth hormone/prolactin axis, stress, and metabolism. Growth Hormone & IGF Research, 33, 23-27.

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For research use only. Not intended for any clinical use.

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