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CNOT4

CNOT4 (CCR4-NOT Transcription Complex Subunit 4) is a Protein Coding gene. Diseases associated with CNOT4 include Adenoiditis. Among its related pathways are Gene Expression and TP53 Regulates Transcription of Cell Cycle Genes. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding.

Full Name

CCR4-NOT Transcription Complex Subunit 4

Function

Has E3 ubiquitin ligase activity, promoting ubiquitination and degradation of target proteins (PubMed:11823428, PubMed:22159038, PubMed:26575292).

Involved in activation of the JAK/STAT pathway (PubMed:11823428, PubMed:22159038).

Catalyzes ubiquitination of methylated RBM15 (PubMed:26575292).

Plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA (PubMed:29861391).

As part of the PINK1-regulated signaling, upon mitochondria damage, ubiquitinates ABCE1 and thereby recruits autophagy receptors to the mitochondrial outer membrane to initiate mitophagy (PubMed:29861391).

Biological Process

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: Reactome
Nuclear-transcribed mRNA poly(A) tail shortening Source: Reactome
Protein autoubiquitination Source: UniProtKB
Protein ubiquitination Source: GO_Central
Regulation of megakaryocyte differentiation Source: UniProtKB
Ubiquitin-dependent protein catabolic process Source: UniProtKB

Cellular Location

Nucleus; Cytoplasm

PTM

Autoubiquitinated.

Anti-CNOT4 antibodies

Mouse Anti-CNOT4 Recombinant Antibody (CBWJC-2867) (CBMAB-C3993WJ)

SDS

Target: CNOT4

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBWJC-2867

Application*: IH

Mouse Anti-CNOT4 Recombinant Antibody (CBXC-2702) (CBMAB-C3771-CQ)

SDS

Target: CNOT4

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXC-2702

Application*: WB, IH

Mouse Anti-CNOT4 Recombinant Antibody (CBXC-2174) (CBMAB-C3768-CQ)

SDS

Target: CNOT4

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXC-2174

Application*: WB, F

Mouse Anti-CNOT4 Recombinant Antibody (CBXC-2226) (CBMAB-C3767-CQ)

SDS

Target: CNOT4

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXC-2226

Application*: WB

Mouse Anti-CNOT4 Recombinant Antibody (CBXC-2796) (CBMAB-C2335-CQ)

SDS

Target: CNOT4

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBXC-2796

Application*: E, WB

Mouse Anti-CNOT4 (AA 190-455) Recombinant Antibody (CBFYC-1997) (CBMAB-C2063-FY)

SDS

Target: CNOT4

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYC-1997

Application*: P, WB

Mouse Anti-CNOT4 Recombinant Antibody (CBFYC-1996) (CBMAB-C2062-FY)

SDS

Target: CNOT4

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYC-1996

Application*: WB

Rabbit Anti-CNOT4 Recombinant Antibody (EG750) (CBMAB-EN905-LY)

SDS

Target: CNOT4

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: EG750

Application*: WB: 1:500~1:1000 IHC: 1:50~1:100 ELISA: 1:40000

Mouse Anti-CNOT4 Recombinant Antibody (CBCNC-229) (CBMAB-C2526-CN)

SDS

Target: CNOT4

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBCNC-229

Application*: E, WB

Mouse Anti-CNOT4 Recombinant Antibody (2A5) (CBMAB-C4622-LY)

SDS

Target: CNOT4

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 2A5

Application*: WB

Mouse Anti-CNOT4 Recombinant Antibody (1H2) (CBMAB-C4231-LY)

SDS

Target: CNOT4

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 1H2

Application*: WB, IH, P

Mouse Anti-CNOT4 Recombinant Antibody (1F9) (CBMAB-C4099-LY)

SDS

Target: CNOT4

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 1F9

Application*: WB

Mouse Anti-CNOT4 Recombinant Antibody (1F10) (CBMAB-C4012-LY)

SDS

Target: CNOT4

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 1F10

Application*: P, WB

Mouse Anti-CNOT4 Recombinant Antibody (343CT14.6.5) (CBMAB-C1002-LY)

SDS

Target: CNOT4

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 343CT14.6.5

Application*: E, WB

Mouse Anti-CNOT4 Recombinant Antibody (3D11) (CBMAB-1399-CN)

SDS

Target: CNOT4

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse

Clone: 3D11

Application*: WB, F

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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