CNOT4

CNOT4 (CCR4-NOT Transcription Complex Subunit 4) is a Protein Coding gene. Diseases associated with CNOT4 include Adenoiditis. Among its related pathways are Gene Expression and TP53 Regulates Transcription of Cell Cycle Genes. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding.

CCR4-NOT Transcription Complex Subunit 4

Has E3 ubiquitin ligase activity, promoting ubiquitination and degradation of target proteins (PubMed:11823428, PubMed:22159038, PubMed:26575292).

Involved in activation of the JAK/STAT pathway (PubMed:11823428, PubMed:22159038).

Catalyzes ubiquitination of methylated RBM15 (PubMed:26575292).

Plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA (PubMed:29861391).

As part of the PINK1-regulated signaling, upon mitochondria damage, ubiquitinates ABCE1 and thereby recruits autophagy receptors to the mitochondrial outer membrane to initiate mitophagy (PubMed:29861391).

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: Reactome
Nuclear-transcribed mRNA poly(A) tail shortening Source: Reactome
Protein autoubiquitination Source: UniProtKB
Protein ubiquitination Source: GO_Central
Regulation of megakaryocyte differentiation Source: UniProtKB
Ubiquitin-dependent protein catabolic process Source: UniProtKB

Nucleus; Cytoplasm

Autoubiquitinated.