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Mouse Anti-CNOT4 Recombinant Antibody (C1002) (V2LY-1206-LY463)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
C1002
Antibody Isotype
IgG2a, κ
Application
WB, IP

Basic Information

Immunogen
Recombinant protein corresponding to CNOT4 of human.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
0.1% gelatin
Preservative
<0.1% sodium azide
Concentration
0.1 mg/ml
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
CCR4-NOT Transcription Complex Subunit 4
Entrez Gene ID
Human4850
Mouse53621
Rat312227
UniProt ID
HumanO95628
MouseQ8BT14
RatQ498M7
Function
Has E3 ubiquitin ligase activity, promoting ubiquitination and degradation of target proteins (PubMed:11823428, PubMed:22159038, PubMed:26575292).

Involved in activation of the JAK/STAT pathway (PubMed:11823428, PubMed:22159038).

Catalyzes ubiquitination of methylated RBM15 (PubMed:26575292).

Plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA (PubMed:29861391).

As part of the PINK1-regulated signaling, upon mitochondria damage, ubiquitinates ABCE1 and thereby recruits autophagy receptors to the mitochondrial outer membrane to initiate mitophagy (PubMed:29861391).
Biological Process
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: Reactome
Nuclear-transcribed mRNA poly(A) tail shortening Source: Reactome
Protein autoubiquitination Source: UniProtKB
Protein ubiquitination Source: GO_Central
Regulation of megakaryocyte differentiation Source: UniProtKB
Ubiquitin-dependent protein catabolic process Source: UniProtKB
Cellular Location
Nucleus; Cytoplasm
PTM
Autoubiquitinated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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