CLDN12

Claudins, such as CLDN12, are components of epithelial cell tight junctions. Tight junctions regulate movement of solutes and ions through the paracellular space and prevent mixing of proteins and lipids in the outer leaflet of the apical and basolateral plasma membrane domains (Acharya et al., 2004).[supplied by OMIM

Full Name

claudin 12

Function

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

Biological Process

Calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules Source: UniProtKB
Maintenance of blood-brain barrier Source: ARUK-UCL

Cellular Location

Cell membrane; Tight junction

Topology

Cytoplasmic: 1-10
Helical: 11-31
Extracellular: 32-87
Helical: 88-108
Cytoplasmic: 109-135
Helical: 136-156
Extracellular: 157-174
Helical: 175-195
Cytoplasmic: 196-244

Anti-CLDN12 antibodies

Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Mouse Anti-CLDN12 Recombinant Antibody (CBXC-0450) (CBMAB-C5185-CQ)

Datasheet

SDS

Target: CLDN12

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBXC-0450

Application*: E

Mouse Anti-CLDN12 Recombinant Antibody (CBXC-1163) (CBMAB-C1429-CQ)

Datasheet

SDS

Target: CLDN12

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBXC-1163

Application*: F, IF

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)