CDX2

This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded protein is a major regulator of intestine-specific genes involved in cell growth an differentiation. This protein also plays a role in early embryonic development of the intestinal tract. Aberrant expression of this gene is associated with intestinal inflammation and tumorigenesis.

Caudal Type Homeobox 2

Caudal Type Homeobox 2; Caudal-Type Homeobox Protein 2; CDX-3; CDX3; Caudal Type Homeo Box Transcription Factor 2; Caudal Type Homeobox Transcription Factor 2; Homeobox Protein MiniCDX2; Homeobox Protein CDX-2; CDX2/AS;

Transcription factor which regulates the transcription of multiple genes expressed in the intestinal epithelium (By similarity).
Binds to the promoter of the intestinal sucrase-isomaltase SI and activates SI transcription (By similarity).
Binds to the DNA sequence 5'-ATAAAAACTTAT-3' in the promoter region of VDR and activates VDR transcription (By similarity).
Binds to and activates transcription of LPH (By similarity).
Activates transcription of CLDN2 and intestinal mucin MUC2 (By similarity).
Binds to the 5'-AATTTTTTACAACACCT-3' DNA sequence in the promoter region of CA1 and activates CA1 transcription (By similarity).
Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. Binds preferentially to methylated DNA (PubMed:28473536).

Animal organ morphogenesis Source: GO_Central
Anterior/posterior axis specification Source: GO_Central
Blood vessel development Source: Ensembl
Cell differentiation Source: GO_Central
Endosome to lysosome transport Source: Ensembl
Establishment or maintenance of epithelial cell apical/basal polarity Source: Ensembl
Intestinal epithelial cell differentiation Source: UniProtKB
Labyrinthine layer development Source: Ensembl
Negative regulation of transcription by RNA polymerase II Source: NTNU_SB
Positive regulation of cell differentiation Source: Ensembl
Positive regulation of cell population proliferation Source: Ensembl
Positive regulation of transcription, DNA-templated Source: Ensembl
Regulation of somitogenesis Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Somatic stem cell population maintenance Source: Ensembl
Trophectodermal cell differentiation Source: Ensembl

Nucleus

Ubiquitinated, leading to its degradation by the proteasome.
Phosphorylation at Ser-60 reduces transactivation capacity. Phosphorylation at Ser-283 reduces transactivation capacity and also increases ubiquitin-dependent proteasome degradation.