CDCA7L

CDCA7L (Cell Division Cycle Associated 7 Like) is a Protein Coding gene. Diseases associated with CDCA7L include Medulloblastoma. Among its related pathways are Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. An important paralog of this gene is CDCA7.

Cell Division Cycle Associated 7 Like

Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1.

Positive regulation of cell population proliferation Source: MGI
Regulation of transcription, DNA-templated Source: InterPro

Cytoplasm; Nucleus. Associates with chromatin. Translocates from cytoplasm to nucleus under dexamethasone induction.

Phosphorylation increases its interaction with PSIP1.