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Mouse Anti-CDCA7L Recombinant Antibody (CBXC-2164) (CBMAB-C5598-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXC-2164
Antibody Isotype
IgG1
Application
WB, IHC

Basic Information

Immunogen
Human recombinant protein fragment corresponding to amino acids 1-337 of human CDCA7L produced in E.coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:2,000
IHC1:150

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4, 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
1 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cell Division Cycle Associated 7 Like
Introduction
CDCA7L (Cell Division Cycle Associated 7 Like) is a Protein Coding gene. Diseases associated with CDCA7L include Medulloblastoma. Among its related pathways are Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. An important paralog of this gene is CDCA7.
Entrez Gene ID
55536
UniProt ID
Q96GN5
Alternative Names
Cell Division Cycle Associated 7 Like; Transcription Factor RAM2; JPO2; R1; Cell Division Cycle-Associated 7-Like Protein; Cell Division Cycle Associated 7-Like; Protein JPO2; RAM2; HR1;
Function
Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1.
Biological Process
Positive regulation of cell population proliferation Source: MGI
Regulation of transcription, DNA-templated Source: InterPro
Cellular Location
Cytoplasm; Nucleus. Associates with chromatin. Translocates from cytoplasm to nucleus under dexamethasone induction.
PTM
Phosphorylation increases its interaction with PSIP1.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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