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CD63

CD63 (CD63 Molecule) is a Protein Coding gene. Diseases associated with CD63 include Hermansky-Pudlak Syndrome and Melanoma. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Innate Immune System. An important paralog of this gene is TSPAN33.
Full Name
CD63 Molecule
Function
Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.
Biological Process
Cell-matrix adhesion Source: UniProtKB
Cell migration Source: UniProtKB
Cellular protein localization Source: MGI
Endosome to melanosome transport Source: UniProtKB
Neutrophil degranulation Source: Reactome
Pigment granule maturation Source: UniProtKB
Platelet degranulation Source: Reactome
Positive regulation of integrin-mediated signaling pathway Source: UniProtKB
Positive regulation of receptor internalization Source: UniProtKB
Protein transport Source: UniProtKB-KW
Regulation of potassium ion transmembrane transport Source: MGI
Regulation of vascular endothelial growth factor signaling pathway Source: UniProtKB
Cellular Location
Lysosome membrane; Cell membrane; Extracellular exosome; Late endosome membrane; Multivesicular body; Melanosome; Cell surface. Also found in Weibel-Palade bodies of endothelial cells (PubMed:10793155). Located in platelet dense granules (PubMed:7682577). Detected in a subset of pre-melanosomes. Detected on intralumenal vesicles (ILVs) within multivesicular bodies (PubMed:21962903).
Topology
Cytoplasmic: 2-11
Helical: 12-32
Extracellular: 33-51
Helical: 52-72
Cytoplasmic: 73-81
Helical: 82-102
Extracellular: 103-203
Helical: 204-224
Cytoplasmic: 225-238
PTM
Palmitoylated at a low, basal level in unstimulated platelets. The level of palmitoylation increases when platelets are activated by thrombin (in vitro).

Anti-CD63 antibodies

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Target: CD63
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: NKI/C-3
Application*: WB, IP, IF, P
Target: CD63
Host: Rabbit
Antibody Isotype: IgG
Specificity: Rat
Clone: CBNH-027
Application*: E
Target: CD63
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: TEA3/18
Application*: F
Target: CD63
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: LAMP3/529
Application*: WB
Target: CD63
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MEM-259
Application*: F, IF, P, IP
Target: CD63
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: MX-49.129.5
Application*: WB, F, IF, IP, E, P
Target: CD63
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXC-1200
Application*: WB, IF, IP, E, P
Target: CD63
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle
Clone: CBXC-2866
Application*: F
Target: CD63
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXC-2498
Application*: IH, WB
Target: CD63
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 001
Application*: P
Target: CD63
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 142
Application*: E
Target: CD63
Host: Rat
Antibody Isotype: IgG2a, λ
Specificity: Mouse, Human
Clone: 7G4.2E8
Application*: WB, F
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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