CD47

CD47 (CD47 Molecule) is a Protein Coding gene. Diseases associated with CD47 include Hereditary Spherocytosis and Neonatal Meningitis. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Innate Immune System. Gene Ontology (GO) annotations related to this gene include thrombospondin receptor activity.

CD47 Molecule

CD47 Molecule; Antigenic Surface Determinant Protein OA3; CD47 Antigen (Rh-Related Antigen, Integrin-Associated Signal Transducer); Antigen Identified By Monoclonal Antibody 1D8; Leukocyte Surface Antigen CD47; Integrin Associated Protein; Rh-Related Antigen; CD47 Glycoprotein;

Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity).
Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection.

ATP export Source: ARUK-UCL
Cell migration Source: ARUK-UCL
Cellular response to interferon-gamma Source: ARUK-UCL
Cellular response to interleukin-1 Source: ARUK-UCL
Cellular response to interleukin-12 Source: ARUK-UCL
Extracellular matrix organization Source: Reactome
Integrin-mediated signaling pathway Source: ProtInc
Leukocyte migration Source: Reactome
Monocyte extravasation Source: ARUK-UCL
Negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis Source: ARUK-UCL
Neutrophil degranulation Source: Reactome
Positive regulation of cell-cell adhesion Source: UniProtKB
Positive regulation of cell population proliferation Source: UniProtKB
Positive regulation of inflammatory response Source: GO_Central
Positive regulation of phagocytosis Source: GO_Central
Positive regulation of stress fiber assembly Source: ARUK-UCL
Positive regulation of T cell activation Source: UniProtKB
Regulation of interferon-gamma production Source: ARUK-UCL
Regulation of interleukin-10 production Source: ARUK-UCL
Regulation of interleukin-12 production Source: ARUK-UCL
Regulation of interleukin-6 production Source: ARUK-UCL
Regulation of nitric oxide biosynthetic process Source: ARUK-UCL
Regulation of tumor necrosis factor production Source: ARUK-UCL

Cell membrane

Extracellular: 19-141
Helical: 142-162
Cytoplasmic: 163-176
Helical: 177-197
Extracellular: 198-207
Helical: 208-228
Cytoplasmic: 229-235
Helical: 236-256
Extracellular: 257-268
Helical: 269-289
Cytoplasmic: 290-323