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Rat Anti-CD47 Recombinant Antibody (MIAP301) (CBMAB-0991-LY)


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Summary

Host Animal
Rat
Specificity
Mouse
Clone
MIAP301
Antibody Isotype
IgG2a, κ
Application
Blocking, IF, in vivo

Basic Information

Immunogen
Intact CD47 purified from placenta.
Host Species
Rat
Specificity
Mouse
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Introduction
Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus. Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection.
Entrez Gene ID
16423
UniProt ID
Q61735
More Infomation

Yu, W. B., Ye, Z. H., Chen, X., Shi, J. J., & Lu, J. J. (2021). The development of small-molecule inhibitors targeting CD47. Drug Discovery Today, 26(2), 561-568.

Lin, A., Razzokov, J., Verswyvel, H., Privat-Maldonado, A., De Backer, J., Yusupov, M., ... & Bogaerts, A. (2021). Oxidation of innate immune checkpoint cd47 on cancer cells with non-thermal plasma. Cancers, 13(3), 579.

Wang, F., Liu, Y. H., Zhang, T., Gao, J., Xu, Y., Xie, G. Y., ... & Yang, Y. G. (2020). Aging‐associated changes in CD47 arrangement and interaction with thrombospondin‐1 on red blood cells visualized by super‐resolution imaging. Aging cell, 19(10), e13224.

Nigro, A., Ricciardi, L., Salvato, I., Sabbatino, F., Vitale, M., Crescenzi, M. A., ... & Dal Col, J. (2020). Enhanced expression of CD47 is associated with off-target resistance to tyrosine kinase inhibitor gefitinib in NSCLC. Frontiers in immunology, 10, 3135.

Logtenberg, M. E., Scheeren, F. A., & Schumacher, T. N. (2020). The CD47-SIRPα immune checkpoint. Immunity, 52(5), 742-752.

Tal, M. C., Torrez Dulgeroff, L. B., Myers, L., Cham, L. B., Mayer-Barber, K. D., Bohrer, A. C., ... & Hasenkrug, K. J. (2020). Upregulation of CD47 is a host checkpoint response to pathogen recognition. Mbio, 11(3), e01293-20.

Hayat, S. M. G., Bianconi, V., Pirro, M., & Sahebkar, A. (2019). Stealth functionalization of biomaterials and nanoparticles by CD47 mimicry. International journal of pharmaceutics, 569, 118628.

Petralia, M. C., Mazzon, E., Fagone, P., Russo, A., Longo, A., Avitabile, T., ... & Basile, M. S. (2019). Characterization of the pathophysiological role of CD47 in uveal melanoma. Molecules, 24(13), 2450.

Lian, S., Xie, X., Lu, Y., & Jia, L. (2019). Checkpoint CD47 function on tumor metastasis and immune therapy. OncoTargets and therapy, 12, 9105.

Veillette, A., & Chen, J. (2018). SIRPα–CD47 immune checkpoint blockade in anticancer therapy. Trends in immunology, 39(3), 173-184.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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