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CD34

CD34 (CD34 Molecule) is a Protein Coding gene. Diseases associated with CD34 include Dermatofibrosarcoma Protuberans and Gastrointestinal Stromal Tumor. Among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Innate Immune System. Gene Ontology (GO) annotations related to this gene include transcription factor binding and sulfate binding.
Full Name
CD34 Molecule
Function
Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins.
Biological Process
Cell-cell adhesion Source: HGNC-UCL
Cell-matrix adhesion Source: GO_Central
Cell motility Source: UniProtKB
Endothelial cell proliferation Source: UniProtKB
Endothelium development Source: UniProtKB
Extracellular exosome assembly Source: UniProtKB
Glomerular endothelium development Source: UniProtKB
Glomerular filtration Source: UniProtKB
Hematopoietic stem cell proliferation Source: UniProtKB
Hemopoiesis Source: UniProtKB
Leukocyte migration Source: HGNC-UCL
Mesangial cell-matrix adhesion Source: UniProtKB
Metanephric glomerular mesangial cell differentiation Source: UniProtKB
Negative regulation of blood coagulation Source: UniProtKB
Negative regulation of cellular response to heat Source: UniProtKB
Negative regulation of cellular response to hypoxia Source: UniProtKB
Negative regulation of gene expression Source: UniProtKB
Negative regulation of interleukin-2 production Source: UniProtKB
Negative regulation of neuron death Source: UniProtKB
Negative regulation of nitric oxide biosynthetic process Source: UniProtKB
Negative regulation of tumor necrosis factor production Source: UniProtKB
Paracrine signaling Source: UniProtKB
Positive regulation of angiogenesis Source: UniProtKB
Positive regulation of gene expression Source: UniProtKB
Positive regulation of glial cell-derived neurotrophic factor production Source: UniProtKB
Positive regulation of granulocyte colony-stimulating factor production Source: UniProtKB
Positive regulation of interleukin-10 production Source: UniProtKB
Positive regulation of odontogenesis Source: UniProtKB
Positive regulation of transforming growth factor beta production Source: UniProtKB
Positive regulation of vasculogenesis Source: UniProtKB
Regulation of blood pressure Source: UniProtKB
Regulation of immune response Source: Reactome
Signal transduction Source: UniProtKB
Stem cell proliferation Source: UniProtKB
Tissue homeostasis Source: UniProtKB
Transdifferentiation Source: UniProtKB
Vascular wound healing Source: UniProtKB
Cellular Location
Membrane
Topology
Extracellular: 32-290
Helical: 291-311
Cytoplasmic: 312-385
PTM
Highly glycosylated.
Phosphorylated on serine residues by PKC.

Anti-CD34 antibodies

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Target: CD34
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 013
Application*: WB, E, P, F, IF, IP
Target: CD34
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 028
Application*: E
Target: CD34
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: ICO115
Application*: WB, F, IF, IP
Target: CD34
Host: Human
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: QBEnd/10
Application*: WB, IH, IP
Target: CD34
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 305
Application*: E
Target: CD34
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse, Rabbit
Clone: MEC 14.7
Application*: WB, F, E, IH, IF, IP
Target: CD34
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: CBFYH-0063
Application*: WB, IP, P, IF, F
Target: CD34
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Dog
Clone: CBFYC-0265
Application*: F, IH, WB, in vivo
Target: CD34
Host: Mouse
Antibody Isotype: IgG1
Specificity: Chicken
Clone: CBFYC-0412
Application*: WB, E, IF
Target: CD34
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYC-1219
Application*: WB, E, P, IF, IP
Target: CD34
Host: Mouse
Antibody Isotype: IgM
Specificity: Mouse, Rat
Clone: CBFYC-1220
Application*: WB, IP, IF
Target: CD34
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBFYC-1221
Application*: WB, E, P, IF, IP
Target: CD34
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBFYC-1222
Application*: F
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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