CD164

Sialomucins are a heterogeneous group of secreted or membrane-associated mucins that appear to play 2 key but opposing roles in vivo: first as cytoprotective or antiadhesive agents, and second as adhesion receptors. CD164 is a type I integral transmembrane sialomucin that functions as an adhesion receptor (Watt et al., 1998 [PubMed 9680353]; Forde et al., 2007 [PubMed 17077324]).[supplied by OMIM

Full Name

CD164 molecule, sialomucin

Function

Sialomucin that may play a key role in hematopoiesis by facilitating the adhesion of CD34+ cells to the stroma and by negatively regulating CD34+CD38(lo/-) cell proliferation. Modulates the migration of umbilical cord blood CD133+ cells and this is mediated through the CXCL12/CXCR4 axis. May play an important role in prostate cancer metastasis and the infiltration of bone marrow by cancer cells. Promotes myogenesis by enhancing CXCR4-dependent cell motility. Positively regulates myoblast migration and promotes myoblast fusion into myotubes (By similarity).

Biological Process

Cell adhesion Source: MGI
Hemopoiesis Source: UniProtKB
Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: MGI
Immune response Source: ProtInc
Multicellular organism development Source: ProtInc
Muscle organ development Source: UniProtKB-KW
Negative regulation of cell adhesion Source: UniProtKB
Negative regulation of cell population proliferation Source: ProtInc
Signal transduction Source: ProtInc

Cellular Location

Lysosome membrane; Endosome membrane; Cell membrane
Isoform 2: Secreted

Involvement in disease

Deafness, autosomal dominant, 66 (DFNA66): A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.

Topology

Extracellular: 24-162
Helical: 163-183
Cytoplasmic: 184-197

PTM

Highly N- and O-glycosylated; contains sialic acid.
The motif Ser-Gly may serve as the site of attachment of a glycosaminoglycan side chain.