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Rat Anti-4-1BB Recombinant Antibody (V2-1558) (CBMAB-0953-LY)


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Published Data
Rat Anti-4-1BB Recombinant Antibody (LOB12.3) (CBMAB-0953-LY) in IHC
Distinct activity and toxicity profiles of anti-4-1BB Abs. a WT Balb/c (n = 4-5/group) or b B6 mice (n = 5/group) were injected subcutaneously with 1 × 106 (a) CT-26 (b) B16-OVA cells, then 200 μg of anti-4-1BB (3H3 or LOB12.3) or control IgG was administered on days 9, 16, and 23. Tumor growth was measured twice a week. c, d Twenty-one days after the first treatment, serum ALT levels in a, b were measured e Naive Balb/c (n = 4/group) or f B6 mice (n = 4/group) were treated with 200 μg of anti-4-1BB (3H3 or LOB12.3) or control IgG on days 0, 7, and 14, and serum ALT levels were measured on day 21. g Same as in e, f liver tissue was stained by HE. Mean ± SEM are shown. *p < 0.05, **p < 0.01 compared with control group or as indicated. Scale bar: 50 µm ...View More
Qi, X., Li, F., Wu, Y., Cheng, C., Han, P., Wang, J., & Yang, X. (2019). Optimization of 4-1BB antibody for cancer immunotherapy by balancing agonistic strength with FcγR affinity. Nature communications, 10(1), 2141.

Summary

Host Animal
Rat
Specificity
Mouse
Clone
V2-1558
Antibody Isotype
IgG1
Application
Activation

Basic Information

Immunogen
Mouse CD137 human Fc fusion protein.
Specificity
Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Endotoxin
<2EU/mg
Format
Liquid
Buffer
PBS, pH8.0
Preservative
None
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Introduction
Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation.
Entrez Gene ID
21942
UniProt ID
P20334
Alternative Names
ILA; Ly63; Tnfrsf9; Cd137; CDw137; AA408498; AI325004; A930040I11Rik
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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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