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CCR8

CCR8 (C-C Motif Chemokine Receptor 8) is a Protein Coding gene. Diseases associated with CCR8 include Molluscum Contagiosum and Kaposi Sarcoma. Among its related pathways are Akt Signaling and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and chemokine receptor activity. An important paralog of this gene is CCR4.

Full Name

C-C Motif Chemokine Receptor 8

Function

Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection.

Biological Process

Calcium-mediated signaling Source: GO_Central
Cell adhesion Source: ProtInc
Cell chemotaxis Source: GO_Central
Chemotaxis Source: ProtInc
G protein-coupled receptor signaling pathway Source: Reactome
Immune response Source: GO_Central
Positive regulation of cytosolic calcium ion concentration Source: GO_Central

Cellular Location

Cell membrane

Topology

Extracellular: 1-35
Helical: 36-63
Cytoplasmic: 64-73
Helical: 74-93
Extracellular: 94-107
Helical: 108-129
Cytoplasmic: 130-146
Helical: 147-171
Extracellular: 172-202
Helical: 203-222
Cytoplasmic: 223-238
Helical: 239-263
Extracellular: 264-280
Helical: 281-304
Cytoplasmic: 305-355

Anti-CCR8 antibodies

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Rat Anti-CCR8 Recombinant Antibody (CBXC-0996) (CBMAB-C1258-CQ)

SDS

Target: CCR8

Host: Rat

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBXC-0996

Application*: F, B

Rabbit Anti-CCR8 Recombinant Antibody (CBXC-0948) (CBMAB-C1210-CQ)

SDS

Target: CCR8

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse

Clone: CBXC-0948

Application*: F

Mouse Anti-CCR8 Recombinant Antibody (CBYY-C0224) (CBMAB-C0647-YY)

SDS

Target: CCR8

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBYY-C0224

Application*: F

Human Anti-CCR8 Recombinant Antibody (CBFYC-0354) (CBMAB-C0393-FY)

SDS

Target: CCR8

Host: Human

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYC-0354

Application*: F, E

Rabbit Anti-CCR8 Recombinant Antibody (CBFYC-0154) (CBMAB-C0176-FY)

SDS

Target: CCR8

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CBFYC-0154

Application*: WB, IF, IC

Human Anti-CCR8 Recombinant Antibody (2C6) (CBMAB-C3088-LY)

SDS

Target: CCR8

Host: Human

Antibody Isotype: IgG1

Specificity: Human

Clone: 2C6

Application*: F

Human Anti-CCR8 Recombinant Antibody (2C10) (CBMAB-C0454-LY)

SDS

Target: CCR8

Host: Human

Antibody Isotype: IgG1

Specificity: Human

Clone: 2C10

Application*: F

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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