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Human Anti-CCR8 Recombinant Antibody (2C10) (CBMAB-C0454-LY)


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Summary

Host Animal
Human
Specificity
Human
Clone
2C10
Antibody Isotype
IgG1
Application
FC

Basic Information

Immunogen
Recombinant Human CCR8 protein.
Host Species
Human
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4, 50% glycerol
Preservative
0.03% sodium azide
Concentration
1 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
C-C Motif Chemokine Receptor 8
Introduction
CCR8 (C-C Motif Chemokine Receptor 8) is a Protein Coding gene. Diseases associated with CCR8 include Molluscum Contagiosum and Kaposi Sarcoma. Among its related pathways are Akt Signaling and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and chemokine receptor activity.
An important paralog of this gene is CCR4.
Entrez Gene ID
Human1237
Rat301066
UniProt ID
HumanP51685
RatD4ADE0
Function
Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection.
Biological Process
Calcium-mediated signaling Source: GO_Central
Cell adhesion Source: ProtInc
Cell chemotaxis Source: GO_Central
Chemotaxis Source: ProtInc
G protein-coupled receptor signaling pathway Source: Reactome
Immune response Source: GO_Central
Positive regulation of cytosolic calcium ion concentration Source: GO_Central
Cellular Location
Cell membrane
Topology
Extracellular: 1-35
Helical: 36-63
Cytoplasmic: 64-73
Helical: 74-93
Extracellular: 94-107
Helical: 108-129
Cytoplasmic: 130-146
Helical: 147-171
Extracellular: 172-202
Helical: 203-222
Cytoplasmic: 223-238
Helical: 239-263
Extracellular: 264-280
Helical: 281-304
Cytoplasmic: 305-355
More Infomation

Verhaegen, Y., Liu, L., Nguyen, T. T., Van Loy, T., Voet, A. R., Schols, D., ... & De Jonghe, S. (2021). Palladium-catalyzed cross-coupling reactions on a bromo-naphthalene scaffold in the search for novel human CC chemokine receptor 8 (CCR8) antagonists. Bioorganic Chemistry, 107, 104560.

Fujikawa, M., Koma, Y. I., Hosono, M., Urakawa, N., Tanigawa, K., Shimizu, M., ... & Yokozaki, H. (2021). Chemokine (CC Motif) Ligand 1 Derived from Tumor-Associated Macrophages Contributes to Esophageal Squamous Cell Carcinoma Progression via CCR8-Mediated Akt/Proline-Rich Akt Substrate of 40 kDa/Mammalian Target of Rapamycin Pathway. The American Journal of Pathology, 191(4), 686-703.

Nagai, R., Nagira, M., Nogami, W., Hirata, M., Ueyama, A., Yoshikawa, M., ... & Nagira, Y. (2021). 873 S-531011, a novel anti-human CCR8 antibody: anti-tumor responses through depletion of tumor-infiltrating CCR8-positive Tregs.

Korbecki, J., Grochans, S., Gutowska, I., Barczak, K., & Baranowska-Bosiacka, I. (2020). CC chemokines in a tumor: a review of pro-cancer and anti-cancer properties of receptors CCR5, CCR6, CCR7, CCR8, CCR9, and CCR10 ligands. International journal of molecular sciences, 21(20), 7619.

Cadilha, B. L., Dorman, K., Huynh, D., Lorenzini, T., Vänttinen, M., Benmebarek, M. R., ... & Kobold, S. (2020). P06. 03 CC chemokine receptor 8 tumor-directed recruitment enables CAR T cells to reject solid tumors.

Dépis, F., Hu, C., Weaver, J., McGrath, L., Klebanov, B., Buggé, J., ... & Shaffer, D. R. (2020). Preclinical evaluation of JTX-1811, an anti-CCR8 antibody with enhanced ADCC activity, for preferential depletion of tumor-infiltrating regulatory T cells.

Berenguer, J., Lagerweij, T., Zhao, X. W., Dusoswa, S., Van Der Stoop, P., Westerman, B., ... & Wurdinger, T. (2018). Glycosylated extracellular vesicles released by glioblastoma cells are decorated by CCL18 allowing for cellular uptake via chemokine receptor CCR8. Journal of extracellular vesicles, 7(1), 1446660.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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