CACYBP

The protein encoded by this gene is a calcyclin binding protein. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Calcyclin Binding Protein

May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).

Aging Source: Ensembl
Cardiac muscle cell differentiation Source: Ensembl
Cellular response to calcium ion Source: Ensembl
Cellular response to leukemia inhibitory factor Source: Ensembl
Heart development Source: GO_Central
Negative regulation of cell death Source: Ensembl
Positive regulation of DNA replication Source: Ensembl
Response to growth hormone Source: Ensembl

Nucleus; Cytoplasm. Cytoplasmic at low calcium concentrations. In neuroblastoma cells, after a retinoic acid (RA) induction and calcium increase, it localizes in both the nucleus and cytoplasm. The nuclear fraction may be phosphorylated.

Phosphorylated on serine residues. Phosphorylated upon induction by RA or at high calcium concentrations.