C5AR2

This gene encodes a G-protein coupled receptor 1 family member involved in the complement system of the innate immune response. Unlike classical G-protein coupled receptors, the encoded protein does not associate with intracellular G-proteins. It may instead modulate signal transduction through the beta-arrestin pathway, and may alternatively act as a decoy receptor. This gene may be involved in coronary artery disease and in the pathogenesis of sepsis. Alternative splicing results in multiple transcript variants.

complement component 5a receptor 2

Receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C5adesArg respectively. Couples weakly to G(i)-mediated signaling pathways.

Chemotaxis Source: InterPro
Complement receptor mediated signaling pathway Source: GO_Central
G protein-coupled receptor signaling pathway Source: Reactome
Inflammatory response Source: GO_Central
Negative regulation of interleukin-6 production Source: UniProtKB
Negative regulation of neutrophil chemotaxis Source: UniProtKB
Negative regulation of tumor necrosis factor production Source: UniProtKB
Phospholipase C-activating G protein-coupled receptor signaling pathway Source: GO_Central
Positive regulation of cytosolic calcium ion concentration Source: GO_Central
Positive regulation of epithelial cell proliferation Source: InterPro
Positive regulation of ERK1 and ERK2 cascade Source: InterPro
Regulation of complement activation Source: Reactome
Regulation of interleukin-8 production Source: UniProtKB

Cell membrane

Extracellular: 1-38 aa
Helical: 39-61 aa
Cytoplasmic: 62-72 aa
Helical: 73-95 aa
Extracellular: 96-114 aa
Helical: 115-137 aa
Cytoplasmic: 138-149 aa
Helical: 150-172 aa
Extracellular: 173-202 aa
Helical: 203-225 aa
Cytoplasmic: 226-237 aa
Helical: 238-260 aa
Extracellular: 261-274 aa
Helical: 275-294 aa
Cytoplasmic: 295-337 aa