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Mouse Anti-C5AR2 Recombinant Antibody (CBXC-1522) (CBMAB-C3517-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXC-1522
Antibody Isotype
IgG2a, κ
Application
FC

Basic Information

Immunogen
L1.2 cells transfected with human C5aR2.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
FC2-6 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
15 mM sodium azide
Concentration
1 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
complement component 5a receptor 2
Entrez Gene ID
319430
UniProt ID
E9PVQ2
Alternative Names
C5L2; GPF77; GPR77
Function
Receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C5adesArg respectively. Couples weakly to G(i)-mediated signaling pathways.
Biological Process
Chemotaxis Source: InterPro
Complement receptor mediated signaling pathway Source: GO_Central
G protein-coupled receptor signaling pathway Source: Reactome
Inflammatory response Source: GO_Central
Negative regulation of interleukin-6 production Source: UniProtKB
Negative regulation of neutrophil chemotaxis Source: UniProtKB
Negative regulation of tumor necrosis factor production Source: UniProtKB
Phospholipase C-activating G protein-coupled receptor signaling pathway Source: GO_Central
Positive regulation of cytosolic calcium ion concentration Source: GO_Central
Positive regulation of epithelial cell proliferation Source: InterPro
Positive regulation of ERK1 and ERK2 cascade Source: InterPro
Regulation of complement activation Source: Reactome
Regulation of interleukin-8 production Source: UniProtKB
Cellular Location
Cell membrane
Topology
Extracellular: 1-38 aa
Helical: 39-61 aa
Cytoplasmic: 62-72 aa
Helical: 73-95 aa
Extracellular: 96-114 aa
Helical: 115-137 aa
Cytoplasmic: 138-149 aa
Helical: 150-172 aa
Extracellular: 173-202 aa
Helical: 203-225 aa
Cytoplasmic: 226-237 aa
Helical: 238-260 aa
Extracellular: 261-274 aa
Helical: 275-294 aa
Cytoplasmic: 295-337 aa
More Infomation

Wu, M. C., Lee, J. D., Ruitenberg, M. J., & Woodruff, T. M. (2020). Absence of the C5a Receptor C5aR2 Worsens Ischemic Tissue Injury by Increasing C5aR1-Mediated Neutrophil Infiltration. The Journal of Immunology, 205(10), 2834-2839.

Miyabe, Y., Miyabe, C., Mani, V., Mempel, T. R., & Luster, A. D. (2019). Atypical complement receptor C5aR2 transports C5a to initiate neutrophil adhesion and inflammation. Science immunology, 4(35).

Li, X. X., Lee, J. D., Kemper, C., & Woodruff, T. M. (2019). The complement receptor C5aR2: a powerful modulator of innate and adaptive immunity. The Journal of Immunology, 202(12), 3339-3348.

Nabizadeh, J. A., Manthey, H. D., Panagides, N., Steyn, F. J., Lee, J. D., Li, X. X., ... & Rolfe, B. E. (2019). C5a receptors C5aR1 and C5aR2 mediate opposing pathologies in a mouse model of melanoma. The FASEB Journal, 33(10), 11060-11071.

Verghese, D. A., Demir, M., Chun, N., Fribourg, M., Cravedi, P., Llaudo, I., ... & Heeger, P. S. (2018). T cell expression of C5a receptor 2 augments murine regulatory T cell (TREG) generation and TREG-dependent cardiac allograft survival. The Journal of Immunology, 200(6), 2186-2198.

Orrem, H. L., Nilsson, P. H., Pischke, S. E., Kleveland, O., Yndestad, A., Ekholt, K., ... & Mollnes, T. E. (2018). IL-6 receptor inhibition by tocilizumab attenuated expression of C5a receptor 1 and 2 in non-ST-elevation myocardial infarction. Frontiers in immunology, 9, 2035.

Zhang, T., Garstka, M. A., & Li, K. (2017). The controversial C5a receptor C5aR2: its role in health and disease. Journal of immunology research, 2017.

Kovtun, A., Bergdolt, S., Hägele, Y., Matthes, R., Lambris, J. D., Huber-Lang, M., & Ignatius, A. (2017). Complement receptors C5aR1 and C5aR2 act differentially during the early immune response after bone fracture but are similarly involved in bone repair. Scientific reports, 7(1), 1-12.

Poppelaars, F., van Werkhoven, M. B., Kotimaa, J., Veldhuis, Z. J., Ausema, A., Broeren, S. G., ... & Seelen, M. A. (2017). Critical role for complement receptor C5aR2 in the pathogenesis of renal ischemia‐reperfusion injury. The FASEB Journal, 31(7), 3193-3204.

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For research use only. Not intended for any clinical use.

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